PD159790
PD159790 is a selective endothelin-converting enzyme-1 (ECE-1) inhibitor, with an EC50 of 28.1 μM.
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- CAS. Nr.: 179598-53-9
- Formel: C16H18F3IN4
- Molecular Weight:450.24
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
PD159790 (30 μM, pH = 6.9) inhibits ECE activity[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 179598-53-9
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Molecular Weight 450.24
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Formel C16H18F3IN4
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SMILES
FC(F)(F)C1=NC(NC2CN(CCC2)CC)=C3C=C(C=CC3=N1)I
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Janet Maguire, et al. Alternative pathway to endothelin-converting enzyme for the synthesis of endothelin in human blood vessels. J Cardiovasc Pharmacol. 2004 Nov:44 Suppl 1:S27-9. [Content Brief]
[2]. F D Russell, et al. Evidence for intracellular endothelin-converting enzyme-2 expression in cultured human vascular endothelial cells. Circ Res. 1999 Apr 30;84(8):891-6. [Content Brief]
[3]. K Ahn, et al. Novel selective quinazoline inhibitors of endothelin converting enzyme-1. Biochem Biophys Res Commun. 1998 Feb 4;243(1):184-90. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PD159790 Related Classifications
HY-119545 Related Classifications
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