Penicillinase
Based on 1 Customer Validation
Penicillinase is an enzyme capable of hydrolyzing penicillin. Penicillinase converts penicillin into penicilloic acid, which has no antigenicity, and destroys the antibacterial, antigenic and epileptogenic properties of penicillin. Penicillinase shortens the duration of penicillin-induced seizures and neutralizes the ability of penicillin to form epileptogenic foci. Penicillinase can be used in research related to penicillin hypersensitivity and penicillin-induced encephalopathy.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 9001-74-5
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
Penicillinase destroys penicillin in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
Topical administration of penicillinase prevents or eliminates penicillin-induced focal epileptogenic foci in acutely prepared adult cats without altering normal cortical electroencephalographic activity, but it has no effect on strychnine-induced epilepsy[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:unspecified strain (adult, epilepsy induced by intramuscular injection of 325,000 units/kg aqueous Na penicillin G)[2]
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Dosage:800,000 units
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Administration:i.v., over 2 minutes; i.m., single dose
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Result:Reduced frequency of penicillin-induced bilaterally synchronous 4- to 5-per-second spike-wave bursts and associated behavioral twitches, with complete disappearance by 3 hours after initial penicillin injection.
Eliminated penicillin-induced seizure activity without tachycardia or other side effects when administered i.m.
Shortened the duration of EEG abnormalities from at least six hours (untreated) to 3 hours.
EC Number
3.5.2.6
Enzyme Activity
≥120000 U/mL
Unit Definition
One unit is defined as the amount of enzyme required to hydrolyze one penicillin G per hour at 37ºC, pH 7.0
Chemical Information
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CAS. Nr. 9001-74-5
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Appearance Liquid
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Color Colorless to light yellow
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SMILES
[Penicillinase]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Reinheit & Dokumentation
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Data Sheet (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Penicillinase Related Classifications
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