Propargyl-PEG2-NHS ester
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Propargyl-PEG2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG2-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- Reinheit: ≥98.0%
- CAS. Nr.: 2512228-06-5
- Formel: C12H15NO6
- Molecular Weight:269.25
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Speicherung:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2512228-06-5
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Appearance Liquid (Density: 1.28 g/cm3)
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Molecular Weight 269.25
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Formel C12H15NO6
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Color Colorless to light yellow
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SMILES
O=C(CCOCCOCC#C)ON1C(CCC1=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 250 mg/mL (928.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7140 mL | 18.5701 mL | 37.1402 mL | 92.8505 mL |
| 5 mM | 0.7428 mL | 3.7140 mL | 7.4280 mL | 18.5701 mL | |
| 10 mM | 0.3714 mL | 1.8570 mL | 3.7140 mL | 9.2851 mL | |
| 15 mM | 0.2476 mL | 1.2380 mL | 2.4760 mL | 6.1900 mL | |
| 20 mM | 0.1857 mL | 0.9285 mL | 1.8570 mL | 4.6425 mL | |
| 25 mM | 0.1486 mL | 0.7428 mL | 1.4856 mL | 3.7140 mL | |
| 30 mM | 0.1238 mL | 0.6190 mL | 1.2380 mL | 3.0950 mL | |
| 40 mM | 0.0929 mL | 0.4643 mL | 0.9285 mL | 2.3213 mL | |
| 50 mM | 0.0743 mL | 0.3714 mL | 0.7428 mL | 1.8570 mL | |
| 60 mM | 0.0619 mL | 0.3095 mL | 0.6190 mL | 1.5475 mL | |
| 80 mM | 0.0464 mL | 0.2321 mL | 0.4643 mL | 1.1606 mL | |
| 100 mM | 0.0371 mL | 0.1857 mL | 0.3714 mL | 0.9285 mL |
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