BTN2A2
BTN2A2 is a widely expressed butyrophilin found on dendritic cells, monocytes, B cells and several epithelial tissues. Functionally it stands out among family members as a T cell co-inhibitory ligand: engagement of BTN2A2 dampens TCR-driven proliferation, cytokine production and cytotoxicity, acting through a receptor system that is not yet fully defined. Its gene lies adjacent to BTN2A1 in the butyrophilin locus, and the encoded protein carries two extracellular Ig-like domains followed by a B30.2-like intracellular region. Because of this suppressive activity, BTN2A2 is being evaluated as an immune checkpoint target in cancer immunotherapy.
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BTN2A2 Recombinant Proteins (3)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
