CD177
CD177 is a glycosylphosphatidylinositol-anchored protein found on a variable subpopulation of neutrophils, roughly half of circulating granulocytes in positive individuals, where it constitutes the clinically important NB1 (HNA-2a) neutrophil alloantigen. Anti-CD177 antibodies cause febrile transfusion reactions, neonatal alloimmune neutropenia, and refractoriness to granulocyte transfusion, making the antigen relevant to transfusion medicine. The CD177-high neutrophil fraction is also the preferential target of anti-myeloperoxidase autoantibodies in ANCA-associated vasculitis, linking the molecule to autoimmune pathology. Because expression is bimodal within the granulocyte compartment, anti-CD177 reagents are widely used to resolve neutrophil subpopulations in flow cytometry.
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CD177 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
