IgG2A
IgG2a is a mouse immunoglobulin subclass with no direct human counterpart, best known as the potent effector antibody of murine Th1-type responses. Its Fc region binds the activating mouse Fc gamma receptors Fc gamma RIII and Fc gamma RIV and fixes complement efficiently, so IgG2a antibodies drive ADCC, opsonization, and inflammation in rodent models, functioning as the rough analog of human IgG1. Many widely used functional and depleting monoclonal antibodies for mouse studies are built on an IgG2a framework. Because genetic variation between laboratory strains determines whether mice express IgG2a or the closely related IgG2c, isotype controls must be selected accordingly.
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IgG2A Recombinant Proteins (4)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
