Integrin beta 6
Integrin beta 6, the ITGB6 gene product, is an epithelium-specific beta subunit known to pair only with alpha V. The resulting alpha V beta 6 heterodimer activates latent TGF-beta-1 and TGF-beta-3 by binding the RGD motif of the latency-associated peptide, coupling integrin ligation to cytokine release that governs wound healing, mucosal immunity and fibrosis. Beta-6 is virtually absent from resting adult airway epithelium but strongly induced during injury and in idiopathic pulmonary fibrosis, providing the rationale for current anti-beta-6 clinical programs. Loss-of-function variants in ITGB6 cause hypomaturation amelogenesis imperfecta affecting dental enamel, and the subunit is overexpressed in several carcinomas as a poor-prognosis marker.
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Integrin beta 6 Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
