PBK
PBK, better known as TOPK, is a MAPKK-like serine/threonine kinase restricted mainly to lymphoid tissues, testis, and proliferating cells. Unusually, PBK is itself activated by phosphorylation of its activation loop by CDK1/cyclin B during mitosis, tying its activity to cell division. Downstream, PBK stimulates the p38 MAPK pathway through MKK3 and MKK6 and phosphorylates multiple mitotic and DNA-damage regulators, contributing to cytokinesis, checkpoint signaling, and apoptosis. PBK is strongly upregulated in lymphomas, multiple myeloma and several solid tumors, and it is pursued as a therapeutic target. Recombinant PBK supports mitotic-signaling research and TOPK-inhibitor development.
-
PBK Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
