PIM2
Located on the X chromosome, PIM2 is the paralog most abundant in brain, hematopoietic cells and testis, and it is strongly upregulated in chronic lymphocytic leukemia, mantle cell lymphoma and multiple myeloma. Like PIM1, it is a constitutively active kinase controlled at the level of expression and stability, and it phosphorylates substrates such as BAD, 4E-BP1 and eIF4B to promote survival and cap-dependent translation. In the nervous system PIM2 can compensate for PIM1 loss, and Pim1/Pim2 double-knockout mice show growth retardation. Its restricted expression pattern makes PIM2 a focus of isoform-selective inhibitor development.
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PIM2 Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
