PLK4
PLK4, or SAK, is the master regulator of centriole duplication and the most divergent member of the Polo-like kinase family, replacing the canonical polo-box array with a unique cryptic polo box flanked by two divergent polo boxes. Acting at the procentriole assembly site, PLK4 phosphorylates STIL, SAS-6 and Cep152-type scaffold components to license exactly one new centriole per cell cycle. Strict autophosphorylation-dependent control of PLK4 levels prevents re-duplication; its overexpression drives centriole amplification, multipolar spindles and aneuploidy, linking it to tumorigenesis. The clinical-stage inhibitor CFI-400945 exemplifies PLK4 as an anticancer target. Recombinant PLK4 supports centrosome biology and inhibitor screening.
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PLK4 Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
