RAD53
The RAD53 group is named for the essential Saccharomyces cerevisiae DNA damage checkpoint kinase Rad53, the fungal ortholog of human checkpoint kinase CHK2. Rad53 integrates signals from Mec1 and Tel1 phosphatidylinositol 3-kinase-related kinases through adaptor proteins such as Rad9, then halts cell cycle progression, stabilizes stalled replication forks, suppresses late-firing origins, and induces DNA repair and nucleotide synthesis genes including ribonucleotide reductase through the downstream kinase Dun1. Two forkhead-associated domains mediate phospho-dependent interactions with damaged chromatin. In kinase phylogenies the RAD53 group sits within the CAMK superfamily, illustrating how a serine/threonine kinase scaffold was adapted for genome surveillance across eukaryotic evolution.
-
RAD53 Recombinant Proteins (4)
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
