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RG-101

(Synonyms: Temavirsen)

RG-101 is a hepatocyte targeted N-acetylgalactosamine conjugated oligonucleotide that antagonises miR-122. miR-122 is an important host factor for hepatitis C virus (HCV) replication.

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  • RG-101 Chemical Structure
    RG-101 Chemical Structure
CAS. Nr.: 1929655-04-8
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  • RG-101 Chemical Structure
    RG-101 Chemical Structure RNA, ([2′-O-(2-methoxyethyl)]A-sp-[2′-O-(2-methoxyethyl)]m5C-sp-[2′-O-(2-methoxyethyl)]A-sp-[2′-O-(2-methoxyethyl)]m5C-sp-[2′-O-(2-methoxyethyl)]m5C-sp-[2′-O-(2-methoxyethyl)]A-sp-[2′-O-(2-methoxyethyl)]m5U-sp-dT-sp-dG-(3′→4′)-sp-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]U-(3′→4′)-sp-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]C-sp-dA-(3′→4′)-sp-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]C-sp-dA-(3′→4′)-sp-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]C-sp-dT-(3′→4′)-sp-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]C-(3′→4′)-sp-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]C-dA), 3′-[[(2S,4R)-1-[29-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2-pyrrolidinyl]methyl hydrogen phosphate]
    1/16
  • RNA, ([2′-O-(2-methoxyethyl)]A-sp-[2′-O-(2-methoxyethyl)]m5C-sp-[2′-O-(2-methoxyethyl)]A-sp-[2′-O-(2-methoxyethyl)]m5C-sp-[2′-O-(2-methoxyethyl)]m5C-sp-[2′-O-(2-methoxyethyl)]A-sp-[2′-O-(2-methoxyethyl)]m5U-sp-dT-sp-dG-(3′→4′)-sp-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]U-(3′→4′)-sp-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]C-sp-dA-(3′→4′)-sp-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]C-sp-dA-(3′→4′)-sp-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]C-sp-dT-(3′→4′)-sp-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]C-(3′→4′)-sp-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]C-dA), 3′-[[(2S,4R)-1-[29-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2-pyrrolidinyl]methyl hydrogen phosphate]