Art. -Nr.: HY-101071

(S)-Monastrol

Name: (S)-Monastrol
Brand: MedChemExpress
SKU: HY-101071
Price: 245.00 USD
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(Synonyms: (+)-Monastrol)

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(S)-Monastrol ((+)-Monastrol) is an allosteric inhibitor of the mitotic kinesin Eg5 that exhibits an antiproliferative effect against several cancer cell lines. (S)-Monastrol arrests mammalian cells in mitosis with monopolar spindles.

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Reinheit : 99.48%
CAS. Nr.: 254753-54-3
Formel: C₁₄H₁₆N₂O₃S
Molecular Weight:292.35

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

(S)-Monastrol Chemical Structure

CAS. Nr.: 254753-54-3

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

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Cellular Effect

Cell Line	Type	Value	Description	References
786-0	GI₅₀	4 μg/mL Compound: BA2, monastrol	Growth inhibition of human 786-0 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human 786-0 cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]
A-431	IC₅₀	53 μg/mL Compound: Monastrol	Cytotoxicity against human A431 cells after 48 hrs by MTT assay Cytotoxicity against human A431 cells after 48 hrs by MTT assay	[PMID: 21620531]
A549	IC₅₀	>10 μM Compound: Monastrol	Cytotoxicity against human A549 cells after 48 hrs by SRB assay Cytotoxicity against human A549 cells after 48 hrs by SRB assay	[PMID: 21856161]
A549	IC₅₀	>100 μM Compound: 1	Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 31673316]
A549	IC₅₀	118 μg/mL Compound: Monastrol	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 21620531]
AGS	IC₅₀	>10 μM Compound: Monastrol	Cytotoxicity against human AGS cells after 48 hrs by SRB assay Cytotoxicity against human AGS cells after 48 hrs by SRB assay	[PMID: 21856161]
BXPC-3	EC₅₀	>100 nM Compound: rac-monastrol	Antiproliferative activity against human BxPC3 cells after 72 hrs by Alamar blue assay Antiproliferative activity against human BxPC3 cells after 72 hrs by Alamar blue assay	[PMID: 20597485]
C6	IC₅₀	>200 μM Compound: 1	Antiproliferative activity against rat C6 cells after 24 hrs by MTS assay Antiproliferative activity against rat C6 cells after 24 hrs by MTS assay	[PMID: 30108989]
C6	IC₅₀	87.83 μM Compound: Manastrol	Cytotoxicity against rat C6 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against rat C6 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30151081]
COLO 205	IC₅₀	164 μg/mL Compound: Monastrol	Cytotoxicity against human COLO205 cells after 48 hrs by MTT assay Cytotoxicity against human COLO205 cells after 48 hrs by MTT assay	[PMID: 21620531]
HCT-116	EC₅₀	1.2 μM Compound: monastrol	Effect on cell cycle progression in human HCT116 cells assessed as mitotic arrest measured by doubling DNA content by fluorescence microscopy Effect on cell cycle progression in human HCT116 cells assessed as mitotic arrest measured by doubling DNA content by fluorescence microscopy	[PMID: 18793847]
HCT-116	EC₅₀	1.5 μM Compound: monastrol	Effect on cell cycle progression in human HCT116 cells assessed as increase in phospho-histone H3 by fluorescence microscopy Effect on cell cycle progression in human HCT116 cells assessed as increase in phospho-histone H3 by fluorescence microscopy	[PMID: 18793847]
HCT-116	EC₅₀	24155 nM Compound: rac-monastrol	Antiproliferative activity against human HCT116 cells after 72 hrs by Alamar blue assay Antiproliferative activity against human HCT116 cells after 72 hrs by Alamar blue assay	[PMID: 20597485]
HCT-116	IC₅₀	>50 μM Compound: Monastrol	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 20934346]
HCT-116	IC₅₀	9 μM Compound: 1	Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay	[PMID: 31673316]
HeLa	IC₅₀	176.9 μM Compound: Monastrol	Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 29908443]
HeLa	IC₅₀	51.3 μM Compound: 1, monastrol	Induction of monoastral spindles in HeLa cells after 7 hrs Induction of monoastral spindles in HeLa cells after 7 hrs	[PMID: 17587586]
HeLa	IC₅₀	6.1 μM Compound: 1, monastrol	Inhibition of Eg5 ATPase activity expressed in HeLa cells after 12 hrs Inhibition of Eg5 ATPase activity expressed in HeLa cells after 12 hrs	[PMID: 17587586]
HL-60(TB)	IC₅₀	0.147 μM Compound: Monastrol	Growth inhibition of human HL-60(TB) cells incubated for 24 hrs by MTT assay Growth inhibition of human HL-60(TB) cells incubated for 24 hrs by MTT assay	[PMID: 28667871]
HT-29	GI₅₀	29.6 μg/mL Compound: BA2, monastrol	Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]
K562	EC₅₀	>100 nM Compound: rac-monastrol	Antiproliferative activity against human K562 cells after 72 hrs by Alamar blue assay Antiproliferative activity against human K562 cells after 72 hrs by Alamar blue assay	[PMID: 20597485]
KB 3-1	EC₅₀	56494 nM Compound: rac-monastrol	Antiproliferative activity against human KB3-1 cells after 72 hrs by Alamar blue assay in presence of zosuquidar Antiproliferative activity against human KB3-1 cells after 72 hrs by Alamar blue assay in presence of zosuquidar	[PMID: 20597485]
KB 3-1	EC₅₀	85114 nM Compound: rac-monastrol	Antiproliferative activity against human KB3-1 cells after 72 hrs by Alamar blue assay Antiproliferative activity against human KB3-1 cells after 72 hrs by Alamar blue assay	[PMID: 20597485]
KB-V1	EC₅₀	45394 nM Compound: rac-monastrol	Antiproliferative activity against human KBV1 cells overexpressing MDR1 after 72 hrs by Alamar blue assay in presence of zosuquidar Antiproliferative activity against human KBV1 cells overexpressing MDR1 after 72 hrs by Alamar blue assay in presence of zosuquidar	[PMID: 20597485]
KB-V1	EC₅₀	99083 nM Compound: rac-monastrol	Antiproliferative activity against human KBV1 cells overexpressing MDR1 after 72 hrs by Alamar blue assay Antiproliferative activity against human KBV1 cells overexpressing MDR1 after 72 hrs by Alamar blue assay	[PMID: 20597485]
MCF7	IC₅₀	45 μg/mL Compound: Monastrol	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 21620531]
MCF7	IC₅₀	59.1 μM Compound: Monastrol	Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 29908443]
MCF7	IC₅₀	73 μM Compound: 1	Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 31673316]
MM1.S	IC₅₀	8.7 μM Compound: 1	Antiproliferative activity against human MM1S cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MM1S cells incubated for 72 hrs by MTT assay	[PMID: 31673316]
MOLT-4	IC₅₀	0.215 μM Compound: Monastrol	Growth inhibition of human MOLT4 cells incubated for 24 hrs by MTT assay Growth inhibition of human MOLT4 cells incubated for 24 hrs by MTT assay	[PMID: 28667871]
NCI/ADR-RES	GI₅₀	22.2 μg/mL Compound: BA2, monastrol	Growth inhibition of human NCI-ADR-RES cells after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-ADR-RES cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]
NCI-H1299	EC₅₀	>100 nM Compound: rac-monastrol	Antiproliferative activity against human NCI-H1299 cells after 72 hrs by Alamar blue assay Antiproliferative activity against human NCI-H1299 cells after 72 hrs by Alamar blue assay	[PMID: 20597485]
NCI-H460	GI₅₀	10.6 μg/mL Compound: BA2, monastrol	Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]
OVCAR-3	GI₅₀	14.4 μg/mL Compound: BA2, monastrol	Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]
PC-3	GI₅₀	5.6 μg/mL Compound: BA2, monastrol	Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]
U138-MG	IC₅₀	>200 μM Compound: 1	Antiproliferative activity against human U138MG cells after 24 hrs by MTS assay Antiproliferative activity against human U138MG cells after 24 hrs by MTS assay	[PMID: 30108989]
U-251	GI₅₀	24 μg/mL Compound: BA2, monastrol	Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]

Chemical Information

CAS. Nr. 254753-54-3
Appearance Solid
Molecular Weight 292.35
Formel C₁₄H₁₆N₂O₃S
Color White to off-white
SMILES

O=C(C1=C(C)NC(N[C@H]1C2=CC=CC(O)=C2)=S)OCC
Synonyms

(+)-Monastrol
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (342.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.4206 mL

17.1028 mL

34.2056 mL

5 mM

0.6841 mL

3.4206 mL

6.8411 mL

10 mM

0.3421 mL

1.7103 mL

3.4206 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (286 KB)
SDS (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Marques LA, et al. Antiproliferative activity of monastrol in human adenocarcinoma (MCF-7) and non-tumor (HB4a) breast cells. Naunyn Schmiedebergs Arch Pharmacol. 2016 Dec;389(12):1279-1288. [Content Brief]

[2]. Mayer TU, et al. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science. 1999 Oct 29;286(5441):971-4. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.4206 mL	17.1028 mL	34.2056 mL	85.5139 mL
	5 mM	0.6841 mL	3.4206 mL	6.8411 mL	17.1028 mL
	10 mM	0.3421 mL	1.7103 mL	3.4206 mL	8.5514 mL
	15 mM	0.2280 mL	1.1402 mL	2.2804 mL	5.7009 mL
	20 mM	0.1710 mL	0.8551 mL	1.7103 mL	4.2757 mL
	25 mM	0.1368 mL	0.6841 mL	1.3682 mL	3.4206 mL
	30 mM	0.1140 mL	0.5701 mL	1.1402 mL	2.8505 mL
	40 mM	0.0855 mL	0.4276 mL	0.8551 mL	2.1378 mL
	50 mM	0.0684 mL	0.3421 mL	0.6841 mL	1.7103 mL
	60 mM	0.0570 mL	0.2850 mL	0.5701 mL	1.4252 mL
	80 mM	0.0428 mL	0.2138 mL	0.4276 mL	1.0689 mL
	100 mM	0.0342 mL	0.1710 mL	0.3421 mL	0.8551 mL

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(S)-Monastrol

Alle Kinesin Isoform-spezifische Produkte anzeigen