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Art. -Nr.: HY-181544

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SB5-171

SB5-171 is a covalent PfCLK3 inhibitor with IC₅₀ values of 10-12 nM. SB5-171shows antiparasitic activity. SB5-171 can be used for the research of malaria.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3088376-92-2
Formel: C₂₉H₃₁N₅O₇S
Molecular Weight:593.65

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

SB5-171 Chemical Structure

CAS. Nr.: 3088376-92-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

SB5-171 is a covalent PfCLK3 inhibitor with IC₅₀ values of 10-12 nM. SB5-171shows antiparasitic activity. SB5-171 can be used for the research of malaria^[1].

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In Vitro

SB5-171 (Compound 14) potently inhibits recombinant full-length PfCLK3 with apparent IC₅₀ values of 10 nM at K_m ATP and 12 nM at 3 mM ATP^[1].
SB5-171 (100 pM-100 μM; 72 h) potently inhibits asexual blood stage growth of P. falciparum 3D7 (EC₅₀ = 104 nM) and chloroquine-resistant Dd2 (EC₅₀ = 267 nM) strains^[1].
SB5-171 (24-48 h) has low cytotoxicity, with a CC₅₀ of >100 μM in HepG2 cells and 25 μM in THP-1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3088376-92-2
Molecular Weight 593.65
Formel C₂₉H₃₁N₅O₇S
SMILES

O=C(O)C1=CC=C(C2=C3C(NC(C4=CC(CN5CCN(C(COS(=O)(NC)=O)=O)CC5)=CC=C4OC)=C3)=NC=C2)C=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Brettell SB, et al. Shaping Antimalarials: A Geometry-First Approach to PfCLK3 Covalent Inhibitors. J Med Chem. 2026;69(3):3378-3395. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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