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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2438 Results for "
decrease
" in MedChemExpress (MCE) Product Catalog:
Products (2438)
2438 Results for "decrease" in MCE Product Catalog:
Art. -Nr.: HY-N8376
CAS. Nr.: 20725-03-5
Synonyms: (±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone
Category:
Flavanonols Plant Flavonoids Anacardiaceae Extract Toxicodendron vernicifluum (Stokes) F. A. Barkl. Extract Phenols Polyphenols
Target:
Art. -Nr.: HY-N8671
CAS. Nr.: 256520-90-8
Art. -Nr.: HY-N9484S
CAS. Nr.: 3028870-62-1
Art. -Nr.: HY-NP0204
Synonyms: Mouse Serum Albumin
Art. -Nr.: HY-P0037
CAS. Nr.: 136208-71-4
Synonyms: Org 30850ANT
Target:
Forschungsgebiete:
Art. -Nr.: HY-P10462
CAS. Nr.: 1403753-45-6
Synonyms: Synthetic anti-inflammatory peptide 15
Forschungsgebiete:
Art. -Nr.: HY-P10462A
Synonyms: Synthetic anti-inflammatory peptide 15 acetate
Forschungsgebiete:
Art. -Nr.: HY-P11291
Target:
Forschungsgebiete:
NNC0165-1273 is a selective NPY Y2 receptor agonist with a Ki of 2 nM and an EC50 of 5.0 nM. NNC0165-1273 blocks Ghrelin-induced cFos expression. NNC0165-1273 reduces nocturnal food intake, attenuates feeding behavior, induces early satiety, and causes dose-dependent decreases in body weight and fat mass in diet-induced obese mice. When used in combination with Semaglutide (HY-114118), NNC0165-1273 reduces preference for high-fat diet, promotes body weight loss, and produces sustained weight loss effects in diet-induced obese rats. NNC0165-1273 can be used in studies related to diet-induced obesity .
Art. -Nr.: HY-P11291B
Target:
Forschungsgebiete:
NNC0165-1273 acetate is a selective NPY Y2 receptor agonist with a Ki of 2 nM and an EC50 of 5.0 nM. NNC0165-1273 acetate blocks Ghrelin-induced cFos expression. NNC0165-1273 acetate reduces nocturnal food intake, attenuates feeding behavior, induces early satiety, and causes dose-dependent decreases in body weight and fat mass in diet-induced obese mice. When used in combination with Semaglutide (HY-114118), NNC0165-1273 acetate reduces preference for high-fat diet, promotes body weight loss, and produces sustained weight loss effects in diet-induced obese rats. NNC0165-1273 acetate can be used in studies related to diet-induced obesity .
Art. -Nr.: HY-P11853
Forschungsgebiete:
cRY9M is a cyclic peptide that binds to FGFR1, with a KD value of 58 nM. cRY9M binds specifically to FGFR1, exhibits enhanced in vivo stability, and shows extremely low degradation in blood, urine and liver homogenate after injection. cRY9M displays significant specific uptake in FGFR1-positive tumor xenograft models, while its uptake decreases in FGFR1-negative tumor models and blocking models. The NOTA-chelated precursor of cRY9M can be labeled with 68Ga to obtain [ 68Ga]Ga-NOTA-cRY9M, which is used for research on non-invasive imaging of FGFR1 expression in non-small cell lung cancer .
Art. -Nr.: HY-P11853A
Forschungsgebiete:
cRY9M acetate is a cyclic peptide that binds to FGFR1, with a KD value of 58 nM. cRY9M acetate binds specifically to FGFR1, exhibits enhanced in vivo stability, and shows extremely low degradation in blood, urine and liver homogenate after injection. cRY9M acetate displays significant specific uptake in FGFR1-positive tumor xenograft models, while its uptake decreases in FGFR1-negative tumor models and blocking models. The NOTA-chelated precursor of cRY9M acetate can be labeled with 68Ga to obtain [ 68Ga]Ga-NOTA-cRY9M, which is used for research on non-invasive imaging of FGFR1 expression in non-small cell lung cancer .
Target:
Forschungsgebiete:
Phosphofructokinase 1 (PFK1) is a glycolytic enzyme and also an allosteric activation target of fructose-2,6-bisphosphate. PFK1 supports cardiac glycolysis to maintain normal cardiac function and mediates adaptive responses to pressure overload. Upregulated expression and activity of PFK1 are associated with the alleviation of pathological changes induced by pressure overload, including diastolic dysfunction, interstitial fibrosis and myocardial hypertrophy. Inhibition of PFK1 redirects glucose carbon flux to the pentose phosphate pathway. PFK1 promotes proliferation, migration and glycolysis of colorectal cancer cells, reduces apoptosis and decreases their radiosensitivity, and shows higher expression levels in radioresistant tumors. PFK1 can be used in research related to diastolic dysfunction heart failure and colorectal cancer .
Target:
Forschungsgebiete:
Phosphofructokinase,Bacillus stearothermophilus is a glycolytic enzyme and also an allosteric activation target of fructose-2,6-bisphosphate. PFK1 supports cardiac glycolysis to maintain normal cardiac function and mediates adaptive responses to pressure overload. Upregulated expression and activity of PFK1 are associated with the alleviation of pathological changes induced by pressure overload, including diastolic dysfunction, interstitial fibrosis and myocardial hypertrophy. Inhibition of PFK1 redirects glucose carbon flux to the pentose phosphate pathway. PFK1 promotes proliferation, migration and glycolysis of colorectal cancer cells, reduces apoptosis and decreases their radiosensitivity, and shows higher expression levels in radioresistant tumors. PFK1 can be used in research related to diastolic dysfunction heart failure and colorectal cancer .
Art. -Nr.: HY-P2970
CAS. Nr.: 37189-34-7
Art. -Nr.: HY-P4277A
Synonyms: DiFMOC-G TFA
Forschungsgebiete:
N,S-Bis-Fmoc-Glutathione TFA (DiFMOC-G TFA) is a GLO2 selective inhibitor with a KA of 0.75 μM against bovine liver GLO2. N,S-Bis-Fmoc-Glutathione TFA competitively inhibits the hydrolysis of S-d-lactoylglutathione to glutathione and D-lactate, leading to intracellular SLG accumulation and protein D-lactylation. N,S-Bis-Fmoc-Glutathione TFA reduces serum inflammatory cytokines and interferons, improves survival in acute inflammation/cytokine storm and TNBS colitis models, and decreases senescence-associated secretory phenotype, immune activation, and inflammation in aging and autoimmune models. N,S-Bis-Fmoc-Glutathione TFA can be used in research on autoimmune diseases and inflammation-related diseases .
Art. -Nr.: HY-P991795
Art. -Nr.: HY-P992540
Target:
Forschungsgebiete:
IBI389 is an anti-Claudin18.2 × CD3 bispecific antibody. IBI389 binds CD3 and Claudin18.2 to engage T cells, induce immune synapse formation, and redirect T cell killing of Claudin18.2-positive tumors. IBI389 increases intratumoral CD3 +/CD8 + T cells, an immuno-inflammatory phenotype, shortens tumor-T cell distance, compensatorily increases regulatory T cells, and elevates IL-2/IFN-γ; IL-4/IL-10/IL-17A/TNF-α are decreased. IBI389 can be used in gastric cancer-related research .
Art. -Nr.: HY-P9S0062
Forschungsgebiete:
Rosnilimab (Mouse IgG2a) is a mouse-derived IgG2a antibody, Rosnilimab. Rosnilimab is a PD-1 agonistic monoclonal antibody. Rosnilimab (Mouse IgG2a) optimizes the inhibitory PD-1 signaling pathway without blocking PD-L1 binding; it also activates moderately activated PD-1 + T cells and eliminates PD-1 high cells, Tfh/Tph cells and Teff cells. Rosnilimab (Mouse IgG2a) reduces the secretion and gene expression of IFN-γ, CXCL13, IL-6 and TNF, decreases macrophage infiltration, and downregulates the gene expression of inflammatory myeloid cells. Rosnilimab (Mouse IgG2a) can be used in studies related to ulcerative colitis .
Art. -Nr.: HY-W018171R
CAS. Nr.: 6515-38-4
Synonyms: TCPy (Standard)
Target:
Forschungsgebiete:
3,5,6-Trichloro-2-pyridinol (Standard) is the analytical standard of 3,5,6-Trichloro-2-pyridinol. This product is intended for research and analytical applications. 3,5,6-Trichloro-2-pyridinol (TCPy) is a chloride of 2-pyridone with oral activity. 3,5,6-Trichloro-2-pyridinol is the main degradation product of the herbicide Triclopyr and the insecticides Chlorpyrifos and chlorpyrifos-methyl. 3,5,6-Trichloro-2-pyridinol is associated with attention deficit hyperactivity disorder (ADHD) and decreased testosterone levels. 3,5,6-Trichloro-2-pyridinol causes hearing loss, hepatotoxicity and nephrotoxicity in mice.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
