Senecivernine
Based on 1 Customer Validation
Senecivernine, a pyrrolizidine alkaloid isolated from Senecio species, exhibits a weakly mutagenic activity.
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- Reinheit : 95.39%
- CAS. Nr.: 72755-25-0
- Formel: C18H25NO5
- Molecular Weight:335.39
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
13.2 μg/mL
Compound: 10
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Toxicity against Cricetulus griseus CHO (Chinese hamster ovary) cell by MTT assay
Toxicity against Cricetulus griseus CHO (Chinese hamster ovary) cell by MTT assay
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10.1016/jbse.2007.08.015 |
| Sf9 | EC50 |
>100 μg/mL
Compound: 10
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Toxicity against Spodoptera frugiperda (fall armyworm) Sf9 cells by MTT assay
Toxicity against Spodoptera frugiperda (fall armyworm) Sf9 cells by MTT assay
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10.1016/jbse.2007.08.015 |
Chemical Information
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CAS. Nr. 72755-25-0
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Appearance Solid
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Molecular Weight 335.39
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Formel C18H25NO5
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Color White to off-white
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SMILES
O=C(O[C@]1([H])CCN2[C@]1([H])C(COC([C@](C)(O)[C@H](C)[C@H]3C)=O)=CC2)C3=C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Protokoll
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Genotoxicity/Mutagenicity Study
The bacterial reverse mutation assay detects point mutations that restore amino-acid prototrophy in auxotrophic Salmonella typhimurium or Escherichia coli tester strains; after exposure to a test article, mutagenic activity is read out as an increased number of revertant colonies on minimal agar compared with the vehicle control. The assay uses tester strains with different mutation targets so that base-substitution and frameshift mutagens can be detected, and testing is performed with and without exogenous mammalian metabolic activation because some chemicals require biotransformation to become mutagenic.
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (479 KB)
- English - EN (479 KB)
- Français - FR (479 KB)
- Deutsch - DE (479 KB)
- Norwegian - NO (479 KB)
- Español - ES (479 KB)
- Swedish - SV (479 KB)
- Italian - IT (479 KB)
- Korean - KR (479 KB)
- Portuguese - PT (479 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Rubiolo P, et, al. Mutagenicity of pyrrolizidine alkaloids in the Salmonella typhimurium/mammalian microsome system. Mutat Res. 1992 Feb; 281(2): 143-7. [Content Brief]
[2]. Wiedenfeld H, et, al. [On the gas-chromatographical determination of the pyrrolizidine alkaloids of some Senecio-species]. Planta Med. 1981 Feb; 41(2): 124-8. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Senecivernine Related Classifications
HY-133591 Related Classifications
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