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Art. -Nr.: HY-134595

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SENP1-IN-2

SENP1-IN-2 is a specific deSUMOylation protease 1 (SENP1) inhibitor extracted from patent CN110627860, Compound 30. SENP1-IN-2 is developed for tumor radiosensitivity enhancement.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2416910-70-6
Formel: C₃₆H₆₀N₂O₅
Molecular Weight:600.87

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

SENP1-IN-2 Chemical Structure

CAS. Nr.: 2416910-70-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

SENP1-IN-2 is a specific deSUMOylation protease 1 (SENP1) inhibitor extracted from patent CN110627860, Compound 30. SENP1-IN-2 is developed for tumor radiosensitivity enhancement^[1].

IC₅₀ & Target

SENP1^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	>20 μM Compound: 43	Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 34688014]

In Vitro

SENP1-IN-2 may improve the sensitivity of tumor cells to irradiation^[1].
SENP1-IN-2 (0.7-20 μM; 72 hours) has cytotoxic for Hella cells with an IC₅₀ of >20 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

Hela cells
Concentration:

0.7 μ M, 2.2 μM, 6.6 μM, 20 μM
Incubation Time:

72 hours
Result:

IC₅₀>20 μM

Chemical Information

CAS. Nr. 2416910-70-6
Molecular Weight 600.87
Formel C₃₆H₆₀N₂O₅
SMILES

CC1(C)[C@@H](O)CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@](C(NCC(N(CCO)CCO)=O)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Li, Yiliang, et al. Preparation of ursolic acid derivatives useful as SENP1 inhibitors and tumor radiosensitizer. CN110627860A.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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