Spiclomazine
Based on 1 Customer Validation
Spiclomazine (Clospirazine) is a potent mutant KRAS(G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer. Spiclomazine can eliminate KRas-GTP levels in KRAS-driven pancreatic cancer and effectively inhibit RAS-mediated signaling. Spiclomazine significantly inhibits tumor progression in mouse renal capsule xenotransplantation models.
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- Reinheit : 99.56%
- CAS. Nr.: 24527-27-3
- Formel: C22H24ClN3OS2
- Molecular Weight:446.03
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
KRAS(G12C) |
Chemical Information
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CAS. Nr. 24527-27-3
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Appearance Solid
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Molecular Weight 446.03
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Formel C22H24ClN3OS2
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Color White to off-white
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SMILES
O=C1CSC2(CCN(CCCN3C4=C(C=CC=C4)SC5=CC=C(Cl)C=C35)CC2)N1
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Synonyms
Clospirazine
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 125 mg/mL (280.25 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.2420 mL | 11.2100 mL | 22.4200 mL | 56.0500 mL |
| 5 mM | 0.4484 mL | 2.2420 mL | 4.4840 mL | 11.2100 mL | |
| 10 mM | 0.2242 mL | 1.1210 mL | 2.2420 mL | 5.6050 mL | |
| 15 mM | 0.1495 mL | 0.7473 mL | 1.4947 mL | 3.7367 mL | |
| 20 mM | 0.1121 mL | 0.5605 mL | 1.1210 mL | 2.8025 mL | |
| 25 mM | 0.0897 mL | 0.4484 mL | 0.8968 mL | 2.2420 mL | |
| 30 mM | 0.0747 mL | 0.3737 mL | 0.7473 mL | 1.8683 mL | |
| 40 mM | 0.0561 mL | 0.2803 mL | 0.5605 mL | 1.4013 mL | |
| 50 mM | 0.0448 mL | 0.2242 mL | 0.4484 mL | 1.1210 mL | |
| 60 mM | 0.0374 mL | 0.1868 mL | 0.3737 mL | 0.9342 mL | |
| 80 mM | 0.0280 mL | 0.1401 mL | 0.2803 mL | 0.7006 mL | |
| 100 mM | 0.0224 mL | 0.1121 mL | 0.2242 mL | 0.5605 mL |
Spiclomazine Related Classifications
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