TC HSD 21
Based on 1 Customer Validation
TC HSD 21 is a selective inhibitor of 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) against related 17β-HSD isozymes, with an IC50 of 14 nM in HeLa cells. TC HSD 21 can be used in the research of prostate cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.0%
- CAS. Nr.: 330203-01-5
- Formel: C17H12BrNO3S2
- Molecular Weight:422.32
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
17β-HSD3 14 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
14 nM
Compound: 1a
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Inhibition of human recombinant 17-beta-HSD3 expressed in human HeLa cells using androstenedione as substrate preincubated for 30 mins prior substrate addition measured after 120 mins by spectrophotometry
Inhibition of human recombinant 17-beta-HSD3 expressed in human HeLa cells using androstenedione as substrate preincubated for 30 mins prior substrate addition measured after 120 mins by spectrophotometry
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[PMID: 22512907] |
| HeLa | IC50 |
14 nM
Compound: 21
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Inhibition of human 17beta-HSD3 expressed in HeLa cells assessed as conversion of 4-androstene-3,17-dione to testosterone
Inhibition of human 17beta-HSD3 expressed in HeLa cells assessed as conversion of 4-androstene-3,17-dione to testosterone
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[PMID: 22137341] |
In Vitro
TC HSD 21 (Compound 21) potently inhibits 17β-HSD3 in HeLa cells expressing human 17β-HSD3, with an IC50 of 14 nM, and exhibits species-dependent potency against 17β-HSD3 in testicular homogenate[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 330203-01-5
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Appearance Solid
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Molecular Weight 422.32
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Formel C17H12BrNO3S2
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Color Light yellow to yellow
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SMILES
O=C1N(C2=CC=C(OC)C=C2)C(S/C1=C\C3=CC=C(O)C(Br)=C3)=S
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : ≥ 250 mg/mL (591.97 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3679 mL | 11.8394 mL | 23.6787 mL | 59.1968 mL |
| 5 mM | 0.4736 mL | 2.3679 mL | 4.7357 mL | 11.8394 mL | |
| 10 mM | 0.2368 mL | 1.1839 mL | 2.3679 mL | 5.9197 mL | |
| 15 mM | 0.1579 mL | 0.7893 mL | 1.5786 mL | 3.9465 mL | |
| 20 mM | 0.1184 mL | 0.5920 mL | 1.1839 mL | 2.9598 mL | |
| 25 mM | 0.0947 mL | 0.4736 mL | 0.9471 mL | 2.3679 mL | |
| 30 mM | 0.0789 mL | 0.3946 mL | 0.7893 mL | 1.9732 mL | |
| 40 mM | 0.0592 mL | 0.2960 mL | 0.5920 mL | 1.4799 mL | |
| 50 mM | 0.0474 mL | 0.2368 mL | 0.4736 mL | 1.1839 mL | |
| 60 mM | 0.0395 mL | 0.1973 mL | 0.3946 mL | 0.9866 mL | |
| 80 mM | 0.0296 mL | 0.1480 mL | 0.2960 mL | 0.7400 mL | |
| 100 mM | 0.0237 mL | 0.1184 mL | 0.2368 mL | 0.5920 mL |
TC HSD 21 Related Classifications
HY-103394 Related Classifications
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