TCO-amine
Based on 1 Customer Validation
TCO-amine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. TCO-amine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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- Reinheit: 99.32%
- CAS. Nr.: 1799962-26-7
- Formel: C12H22N2O2
- Molecular Weight:226.32
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Speicherung:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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Alkyl-Chain |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1799962-26-7
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Appearance Oil
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Molecular Weight 226.32
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Formel C12H22N2O2
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Color Light yellow to yellow
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SMILES
O=C(NCCCN)OC1CC/C=C/CCC1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (441.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (268 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.4185 mL | 22.0926 mL | 44.1852 mL | 110.4631 mL |
| 5 mM | 0.8837 mL | 4.4185 mL | 8.8370 mL | 22.0926 mL | |
| 10 mM | 0.4419 mL | 2.2093 mL | 4.4185 mL | 11.0463 mL | |
| 15 mM | 0.2946 mL | 1.4728 mL | 2.9457 mL | 7.3642 mL | |
| 20 mM | 0.2209 mL | 1.1046 mL | 2.2093 mL | 5.5232 mL | |
| 25 mM | 0.1767 mL | 0.8837 mL | 1.7674 mL | 4.4185 mL | |
| 30 mM | 0.1473 mL | 0.7364 mL | 1.4728 mL | 3.6821 mL | |
| 40 mM | 0.1105 mL | 0.5523 mL | 1.1046 mL | 2.7616 mL | |
| 50 mM | 0.0884 mL | 0.4419 mL | 0.8837 mL | 2.2093 mL | |
| 60 mM | 0.0736 mL | 0.3682 mL | 0.7364 mL | 1.8411 mL | |
| 80 mM | 0.0552 mL | 0.2762 mL | 0.5523 mL | 1.3808 mL | |
| 100 mM | 0.0442 mL | 0.2209 mL | 0.4419 mL | 1.1046 mL |
TCO-amine Related Classifications
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