Art. -Nr.: HY-137910

Tembotrione

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Tembotrione is a herbicide belonging to the HPPD (dioxygenase) inhibitor class with crop selectivity. Tembotrione effectively controls a variety of weeds including broadleaf and gramineous species by disrupting carotenoid synthesis, which leads to chlorophyll degradation and leaf whitening. Mixing Tembotrione with isoxaflutole or adding surfactants optimizes its efficacy and reduces phytotoxicity, with no residual impact on subsequent cruciferous crops, thus helping to increase maize grain yield. The activity of Tembotrione decreases under drought conditions, and under specific conditions (such as double-dose treatment), it may cause reversible yellowing and even yield reduction in crops such as poppy.

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Reinheit: 99.41%
CAS. Nr.: 335104-84-2
Formel: C₁₇H₁₆ClF₃O₆S
Molecular Weight:440.82

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Tembotrione Chemical Structure

CAS. Nr.: 335104-84-2

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Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vivo

Tembotrione (88-176 g a.i. ha^-1; post-emergence foliar spray; single/split application) provides no significant weed control at a single 88 g a.i. ha^-1 dose in infested alkaloid poppy fields, while a split 176 g a.i. ha^-1 dose or a single 88 g a.i. ha^-1 dose following mesotrione application provides significant control of total weeds, Chenopodium album, and Polygonum aviculare (with additional control of Fallopia convolvulus dry weight in wetter conditions), but no control of Papaver rhoeas; all tembotrione doses cause transient, reversible yellowish foliar discoloration in poppy^[1].
Tembotrione (120 g/ha; post-emergence spray; 15-20 DAS; with 1000 mL/ha surfactant) provides the most effective control of mixed grassy (including Bracharia ramosa) and non-grassy weeds in maize, resulting in maximum grain yields of 5333 kg/ha (2009) and 5483 kg/ha (2010) with no residual phytotoxicity to a succeeding mustard crop^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Botond^[1]
Dosage:

88 g a.i. ha^-1 (single application); 176 g a.i. ha^-1 (split dose); 88 g a.i. ha^-1 (post mesotrione application)
Administration:

post-emergence foliar spray; single application (88 g a.i. ha^-1 single/split first dose); split application (176 g a.i. ha^-1: POST 1 and POST 2); single application (88 g a.i. ha^-1 POST 2, post mesotrione)
Result:

Failed to significantly reduce total weed count or dry weight in 2012 or 2013; did not significantly reduce Chenopodium album, Fallopia convolvulus, Papaver rhoeas, or Polygonum aviculare count or dry weight in either year.
Caused transient yellowish discoloration (10-20% of foliage) 7-14 days after application, which resolved by 21 days post-treatment.
Significantly reduced total weed count in 2012 and 2013, and total weed dry weight in 2012 and 2013; significantly reduced Chenopodium album count and dry weight in both years, and Polygonum aviculare count and dry weight in both years; did not significantly reduce Fallopia convolvulus or Papaver rhoeas count or dry weight in either year.
Caused transient yellowish foliar discoloration (10-20% of foliage) 7-14 days after application, which resolved by 21 days post-treatment.

Chemical Information

CAS. Nr. 335104-84-2
Appearance Solid
Molecular Weight 440.82
Formel C₁₇H₁₆ClF₃O₆S
Color White to light yellow
SMILES

O=C1C(C(C2=CC=C(S(=O)(C)=O)C(COCC(F)(F)F)=C2Cl)=O)C(CCC1)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (226.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2685 mL

11.3425 mL

22.6850 mL

5 mM

0.4537 mL

2.2685 mL

4.5370 mL

10 mM

0.2268 mL

1.1342 mL

2.2685 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (5.67 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (5.67 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (701 KB)
- English - EN (701 KB)
- Français - FR (701 KB)
- Deutsch - DE (701 KB)
- Norwegian - NO (701 KB)
- Español - ES (701 KB)
- Swedish - SV (701 KB)
- Italian - IT (701 KB)
- Korean - KR (701 KB)
- Portuguese - PT (701 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Pinke G, et al. Use of mesotrione and tembotrione herbicides for post-emergence weed control in alkaloid poppy (Papaver somniferum)[J]. International Journal of Pest Management, 2014, 60(3): 187-195.

[2]. Singh V P, et al. Bioefficacy of tembotrione against mixed weed complex in maize[J]. Indian journal of weed Science, 2012, 44(1): 1-5.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2685 mL	11.3425 mL	22.6850 mL	56.7125 mL
	5 mM	0.4537 mL	2.2685 mL	4.5370 mL	11.3425 mL
	10 mM	0.2268 mL	1.1342 mL	2.2685 mL	5.6712 mL
	15 mM	0.1512 mL	0.7562 mL	1.5123 mL	3.7808 mL
	20 mM	0.1134 mL	0.5671 mL	1.1342 mL	2.8356 mL
	25 mM	0.0907 mL	0.4537 mL	0.9074 mL	2.2685 mL
	30 mM	0.0756 mL	0.3781 mL	0.7562 mL	1.8904 mL
	40 mM	0.0567 mL	0.2836 mL	0.5671 mL	1.4178 mL
	50 mM	0.0454 mL	0.2268 mL	0.4537 mL	1.1342 mL
	60 mM	0.0378 mL	0.1890 mL	0.3781 mL	0.9452 mL
	80 mM	0.0284 mL	0.1418 mL	0.2836 mL	0.7089 mL
	100 mM	0.0227 mL	0.1134 mL	0.2268 mL	0.5671 mL

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Tembotrione

Metabolic Enzyme Compound Library

Cysteine Targeted Covalent Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Pesticide Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Environmental Pollutant Compound Library

Anti-Infection Compound Library

Metabolism/Protease Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Tembotrione

Metabolic Enzyme Compound Library

Cysteine Targeted Covalent Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Pesticide Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Environmental Pollutant Compound Library

Anti-Infection Compound Library

Metabolism/Protease Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Tembotrione Related Classifications

HY-137910 Related Classifications