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Art. -Nr.: HY-107903

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Thyroglobulin

(Synonyms: Thyroglobulin from bovine)

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Thyroglobulin is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Thyroglobulin acts as a substrate for the synthesis of the thyroid hormones thyroxine (T4) and triiodothyronine (T3), as well as the storage of the inactive forms of thyroid hormone and iodine within the follicular lumen of a thyroid follicle. Thyroglobulin activates Akt kinase activity in FRTL-5 thyroid cell.

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Reinheit: 93%
CAS. Nr.: 9010-34-8

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Thyroglobulin Chemical Structure

CAS. Nr.: 9010-34-8

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- Clinical Trial
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

others

In Vitro

Thyroglobulin (0-10 mg/mL; 12 h to 5 days) stimulates cell growth and DNA synthesis in quiescent FRTL-5 thyroid cells, with maximal activity at 5 mg/mL and reduced activity at higher concentrations^[1].
Thyroglobulin (5 mg/mL; 12 h) does not increase cAMP levels in FRTL-5 thyroid cells^[1].
Thyroglobulin (5 mg/mL; 30-180 min) activates Akt kinase activity in FRTL-5 thyroid cells within 30 min^[1].
Thyroglobulin (0-10 mg/mL) suppresses TPO promoter activity in FRTL-5 thyroid cells in vitro in a concentration-dependent manner^[1].
Thyroglobulin (0-10 mg/mL; 24 h) modulates PDS mRNA expression in FRTL-5 thyroid cells, with maximal expression at 5 mg/mL and reduced expression at higher concentrations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

rat FRTL-5 thyroid cells
Concentration:

5 mg/mL (cell counting; maximal ³H-TdR incorporation); 0-10 mg/mL (³H-TdR concentration dependence)
Incubation Time:

up to 5 days (cell counting); 12 h (³H-TdR incorporation)
Result:

Increased cell number to levels comparable to complete medium (TSH + insulin + 5% serum) over 5 days using 5 mg/mL. Maximized ³H-TdR incorporation at 5 mg/mL, and reduced incorporation at 10 mg/mL.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 9010-34-8
Appearance Solid
Color Light brown to brown
SMILES

[Thyroglobulin]
Synonyms

Thyroglobulin from bovine
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 50 mg/mL (Need ultrasonic)

View the Complete Stock Solution Preparation Table

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Noguchi Y, et al. Thyroglobulin (Tg) induces thyroid cell growth in a concentration-specific manner by a mechanism other than thyrotropin/cAMP stimulation. Biochem Biophys Res Commun. 2010;391(1):890-894. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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