TMC-205
TMC-205 is a natural fungal metabolite with antiproliferative activity against cancer cell lines. TMC-205 is a transcriptional up-regulator of SV40 promoter.
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- CAS. Nr.: 403646-00-4
- Formel: C14H13NO2
- Molecular Weight:227.26
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
Microbial Metabolite |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| HCT-116 | GI50 |
68 μM
Compound: 1, TMC-205
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Antiproliferative activity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTS assay
Antiproliferative activity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTS assay
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[PMID: 25147604] |
Chemical Information
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CAS. Nr. 403646-00-4
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Molecular Weight 227.26
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Formel C14H13NO2
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SMILES
O=C(C1=CNC2=C1C=CC(/C=C/C(C)=C)=C2)O
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Structure Classification
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Initial Source
an unidentified fungus.
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
TMC-205 Related Classifications
HY-114646 Related Classifications
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