TNP-351
TNP-351 is an antifolate. TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 125991-51-7
- Formel: C21H24N6O5
- Molecular Weight:440.45
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
-
HY-10820
Pemetrexed -
HY-13664
Folinic acid calciumBiological Folic Acid -
HY-17556
Folinic acidBiological Folic Acid -
HY-10446
PralatrexateDihydrofolate Reductasean Inhibitor -
HY-10820R
Pemetrexed (Standard) -
HY-13667
Levoleucovorin CalciumAntineoplastic Agent -
HY-17383
Levomefolate calciumFolate Supplement -
HY-13781
Pemetrexed disodium hemipenta hydrateAutophagy Inducer -
HY-14530
PelitrexolGARFT Inhibitor -
HY-B0080
Folinic acid calcium salt pentahydrateEndogenous Metabolite -
HY-17557
Calcium N5-methyltetrahydrofolateFolic Acid Supplement -
HY-10818
LY309887
Biologische Aktivität
Beschreibung
IC50 & Target
Antifolate, DHFR[1]
In Vitro
TNP-351 inhibits the proliferation of mouse L1210 leukemia cells and human CCRF-CEM lymphoblastic leukemia cells with ED50 values of 0.79 and 2.7 nM, respectively[1].
The ED50 values determined for the parent cell line CCRF-CEM, CCRFCEM R30/6 subline, CCRF-CEM R1, and CCRF-CEM R2 are 2.7, 5.8, 94 and 76 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
-
Cell Line:L1210 and CCRF-CEM cells
-
Concentration:0.1, 0.3, 1, 3, and 10 nM for L1210 cells; 0.3, 1, 3, 10, and 30 for CCRF-CEM cells
-
Incubation Time:48 hours for L1210 cells; 72 hours for CCRF-CEM cells
-
Result:The ED50 values were 0.79 and 2.7 nM for L1210 and CCRF-CEM cells, respectively.
Chemical Information
-
CAS. Nr. 125991-51-7
-
Molecular Weight 440.45
-
Formel C21H24N6O5
-
SMILES
O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(CCCC2=CNC3=NC(N)=NC(N)=C32)C=C1)=O
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
-
Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
TNP-351 Related Classifications
HY-19095 Related Classifications
Powered by Bioz