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Art. -Nr.: HY-N19111

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TPI-2

TPI-2 is a metabolite found in the fungus Exophiala sp. TPI-2 induces increased glucose uptake in insulin-sensitive differentiated skeletal muscle cells, with dose-dependent activity. TPI-2 can be used in diabetes-related research.

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CAS. Nr.: 110675-11-1
Formel: C₃₄H₄₈O₁₂
Molecular Weight:648.75

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

TPI-2 Chemical Structure

CAS. Nr.: 110675-11-1

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
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Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Fungal Metabolite

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

In Vitro

TPI-2 (3-100 μM; 24 h) induces a dose-dependent increase in glucose uptake in differentiated L6 rat skeletal muscle myotubes, with activity equivalent to the standard Rosiglitazone (HY-17386)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Differentiation Assay^[1]

Cell Line:

L6 myotubes
Concentration:

3, 10, 30, 100 μM
Incubation Time:

24 h
Result:

Increased glucose uptake in insulin-sensitized differentiated L6 myotubes in a dose-dependent manner.
Exhibited bioactivity comparable to Rosiglitazone (HY-17386).

Chemical Information

CAS. Nr. 110675-11-1
Molecular Weight 648.75
Formel C₃₄H₄₈O₁₂
SMILES

C(OC1=CC(CCCCCCC)=C(C(O)=O)C(O)=C1)(=O)C2=C(O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)C=C(O)C=C2CCCCCCC
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Microorganisms
Exophiala sp
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Gohil AR et al. Exophiarin, an isocoumarin from the fungus Exophiala sp. with antihyperglycemic activity. Nat Prod Res. 2021 May;35(10):1573-1581. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
Chemical Information
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TPI-2

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

TPI-2 Related Classifications

HY-N19111 Related Classifications