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Art. -Nr.: HY-P11830

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UDA-6

UDA-6 is a potent calcitonin and amylin receptor agonist (DACRA). UDA-6 induces weight loss, improves metabolic and hepatic parameters, and stabilizes active receptor states in obesity rats. UDA-6 can be used for the research of obesity.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₁₉₃H₃₁₅N₅₁O₆₂
Molecular Weight:4341.87

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Kundenspezifische Peptidsynthese

UDA-6 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

UDA-6 (30 min) potently and equally activates human AMY₃R and human CTR in HEK-293 cells, with EC₅₀ values of 0.8 pM and 0.6 pM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	AUC_0-inf	AUC_0-t	T_1/2	CL	MRT_0-inf	V_dss	T_max	C_max	Bioavailability
Rat^[1]	1.0 mg/kg	i.v.	142.9 μg·h/mL	142.3 μg·h/mL	15.5 h	7.0 mL/h/kg	21.9 h	0.153 L/kg	/	/	/
Rat^[1]	3.0 mg/kg	s.c.	282.7 μg·h/mL	281.1 μg·h/mL	15.6 h	/	/	/	8 h	6.8 μg/mL	65.9 %

In Vivo

UDA-6 (1-30 nmol/kg; s.c.; single dose) elicits potent, dose-dependent, sustained reductions in body weight and food intake in lean SD rats^[1].
UDA-6 (10-20 nmol/kg; s.c.; daily; 24 days) induces body weight decrease and improves metabolic and hepatic parameters in male DIO SD rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Lean SD Rats (male, 8-10 weeks old)^[1]
Dosage:

1; 3; 10; 30 nmol/kg
Administration:

s.c.; single dose
Result:

Produced a dose-dependent reduction in body weight and cumulative food intake over 96 hours.
Caused transient food intake inhibition over 24 hours followed by rebound at 1 nmol/kg.
Induced a >10% decrease in body weight relative to vehicle controls and sustained food intake suppression over 48 hours at 30 nmol/kg.
Showed no signs of discomfort, emesis, or behavioral abnormalities at any dose.

Animal Model:

DIO SD Rats (male, 600-700 g) maintained on a high fat diet (HFD).^[1]
Dosage:

10 ; 20 nmol/kg
Administration:

s.c.; daily; 24 days
Result:

Resulted in a maximum mean body weight decrease of 13.1% from baseline at 20 nmol/kg.
Reduced ad libitum fed blood glucose levels, serum AST, ALT, TG, TC, and fasting blood glucose levels relative to vehicle controls.
Reduced liver weight, hepatic TG, and hepatic TC.
Partially alleviated liver inflammation and lipid deposition via oil red O and H&E staining.

Chemical Information

Molecular Weight 4341.87
Formel C₁₉₃H₃₁₅N₅₁O₆₂
Sequence

{Pyr}-Ser-His-Leu-Ser-Thr-Ala-Val-Leu-Gly-Arg-cyclo{Lys-(PEG2-Gly-Gly-Ser-Gly-Ser-Gly-γGlu-C20 diacid)-Ser-Ala-Glu-Glu}-His-Lys-Leu-{Aib}-Asp-Tyr-Pro-Arg-Thr-Asp-Val-Gly-Ser-Gly-Ala-Pro-NH2
Sequence Shortening

{Pyr}-SHLSTAVLGR-cyclo{K-(PEG2-GGSGSG-γGlu-C20 diacid)-SAEE}-HKL-{Aib}-DYPRTDVGSGAP-NH2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Zhou Y, et al. Development of a Long-Acting and Stapled Dual Amylin and Calcitonin Receptor Agonist as Monotherapy and Combination with GLP-1R Agonists for the Treatment of Obesity. Bioconjug Chem. 2026;37(1):169-179. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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