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Art. -Nr.: HY-184156

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WSL017

WSL017 is a cytochrome bd oxidase inhibitor with antibacterial activity against Mycobacterium tuberculosis. WSL017 can be used for the research of tuberculosis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₁₇H₁₉NOS
Molecular Weight:285.40

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

WSL017 Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

WSL017 is a cytochrome bd oxidase inhibitor with antibacterial activity against Mycobacterium tuberculosis. WSL017 can be used for the research of tuberculosis^[1].

In Vitro

WSL017 (0.001-100 µM) competitively inhibits Mycobacterium tuberculosis cytochrome bd (Mtbd) in proteoliposomes with an IC₅₀ of 1.4 µM by binding to the quinol-binding site^[1].
WSL017 (0.001-100 µM) competitively inhibits Escherichia coli cytochrome bd (Ecbd) in proteoliposomes with an IC₅₀ of 1.7 µM by binding to the quinol-binding site^[1].
WSL017 (3 µM) does not inhibit Caldalkalibacillus thermarum type 2 NADH dehydrogenase (NDH2) activity, confirming its specific action on cytochrome bd oxidases^[1].
WSL017 (100 µM) binds to the quinol oxidation site of dimeric Escherichia coli cytochrome bd (Ecbd) via hydrophobic interactions, stabilizing the Q-loop in a closed state to inhibit enzyme activity^[1].
WSL017 (25 µM; 7 days) significantly impairs the growth of Mycobacterium tuberculosis H37ra cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

Mycobacterium tuberculosis H37ra cells
Concentration:

25 µM
Incubation Time:

7 days
Result:

Reduced growth to approximately 50% relative to control.
Significantly impaired the growth of Mycobacterium tuberculosis H37ra cells.

Related Protocols :

Chemical Information

Molecular Weight 285.40
Formel C₁₇H₁₉NOS
SMILES

CCC(NC1=CC=C(SC2=CC(C)=CC=C2C)C=C1)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Tijn T. van der Velden, et al. Discovery of a novel chemotype targeting Mycobacterium tuberculosis cytochrome bd through rapid screening and structural elucidation. bioRxiv. 2026.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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