YGT-31
YGT-31 is a modulator for PPARγ with an IC50 of 1.72 μM, and a Ki of 0.62 μM. YGT-31 reduces blood glucose levels and improves insulin resistance in db/db mice type 2 diabetes models, through inhibition of CDK5-mediated PPARγ-Ser273 phosphorylation. YGT-31 exhibits anti-hepatic steatosis effect in mice non-alcoholic fatty liver disease (NAFLD) model.
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- CAS. Nr.: 2835447-74-8
- Formel: C25H18F3NO5
- Molecular Weight:469.41
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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PPARγ 1.72 μM (IC50) |
PPARγ 0.62 μM (Ki) |
Chemical Information
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CAS. Nr. 2835447-74-8
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Molecular Weight 469.41
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Formel C25H18F3NO5
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SMILES
OC1=CC(OCC(NCC2=CC=C(C(F)(F)F)C=C2)=O)=CC3=C1C(C=C(O3)C4=CC=CC=C4)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
YGT-31 Related Classifications
HY-161926 Related Classifications
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