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Art. -Nr.: HY-146957

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ZIKV-IN-1

ZIKV-IN-1 is a potent zika virus inhibitor with an EC₅₀ of 2.8 μM and EC₉₀ of 6.8 μM. ZIKV-IN-1 shows anti-ZIKV activity with low cytotoxicity. ZIKV-IN-1 shows a strong affinity to ZIKV RdRp domain. ZIKV-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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CAS. Nr.: 2762166-06-1
Formel: C₂₁H₁₈BrF₂N₃O₃
Molecular Weight:478.29

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

ZIKV-IN-1 Chemical Structure

CAS. Nr.: 2762166-06-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

ZIKV-IN-1 is a potent zika virus inhibitor with an EC₅₀ of 2.8 μM and EC₉₀ of 6.8 μM. ZIKV-IN-1 shows anti-ZIKV activity with low cytotoxicity. ZIKV-IN-1 shows a strong affinity to ZIKV RdRp domain^[1]. ZIKV-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target

EC₅₀: 2.8 µM (ZIKV)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	>50 μM Compound: 38	Cytotoxicity against human A549 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay Cytotoxicity against human A549 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay	[PMID: 35306290]
Huh-7	CC₅₀	43.8 μM Compound: 38	Cytotoxicity against human Huh-7 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay Cytotoxicity against human Huh-7 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay	[PMID: 35306290]
SNB-19	CC₅₀	49.4 μM Compound: 38	Cytotoxicity against human SNB-19 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay Cytotoxicity against human SNB-19 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay	[PMID: 35306290]
Vero	CC₅₀	46.8 μM Compound: 38	Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition measured after 24 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition measured after 24 hrs by MTT assay	[PMID: 35306290]

In Vitro

ZIKV-IN-1 (compound 38) (0-80 µM) shows anti-ZIKV activity in a dose-dependent manner in A549 cells^[1].
ZIKV-IN-1 (5, 10, 25 µM; 48 h) decreases the expression of ZIKV E and cleaved caspase 3 protein^[1].
ZIKV-IN-1 (1.25, 2.5, 5, 10, 20 µM; 0-250 s) shows strong affinity to ZIKV RdRp domain (K_d=1.87 µM) in A549 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

A549 cells
Concentration:

0-50 µM
Incubation Time:
Result:

Showed anti-ZIKV activity with an EC₅₀ of 2.8 µM, EC₉₀ of 6.8 µM, and CC₅₀ of >50 µM.

Western Blot Analysis^[1]

Cell Line:

A549, Vero cells
Concentration:

5, 10, 25 µM
Incubation Time:

48 h
Result:

Decreased the expression of ZIKV E and cleaved caspase 3 protein.

Cell Cytotoxicity Assay^[1]

Cell Line:

Vero, SNB19, Huh7, A549 cells
Concentration:

0-80 µM
Incubation Time:
Result:

Showed low cytotoxicity with CC₅₀s of 46.8, 49.4, 43.8, 54.1 µM for ZG01 strain of Vero, SNB19, Huh7, A549 cells, and CC₅₀s of 470.5, 485.2, 512.8, 160.8 µM for MR766 strain of Vero, SNB19, Huh7, A549 cells, respectively.

Chemical Information

CAS. Nr. 2762166-06-1
Molecular Weight 478.29
Formel C₂₁H₁₈BrF₂N₃O₃
SMILES

CC1=NC=NC2=C1C(C#CC3=CC(F)=C(C=C3)Br)=CN2[C@@H]4O[C@@H]([C@H]([C@]4(F)C)O)CO
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yao G, et al. Design, synthesis, and biological evaluation of novel 2'-methyl-2'-fluoro-6-methyl-7-alkynyl-7-deazapurine nucleoside analogs as anti-Zika virus agents. Eur J Med Chem. 2022 Apr 15;234:114275. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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