Zoxamide
Based on 1 Customer Validation
Zoxamide (RH-7281) is an oomycete Fungicide and covalent β-tubulin inhibitor. RH-7281 inhibits the assembly of tubulin into microtubules in vitro. Zoxamide binds covalently to β-tubulin, disrupting microtubule assembly and the cytoskeleton. Zoxamide blocks nuclear division in germinated hyphae of Phytophthora capsici and inhibits hyphal growth of Phytophthora capsici.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.05%
- CAS. Nr.: 156052-68-5
- Formel: C14H16Cl3NO2
- Molecular Weight:336.64
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
Studies show that all field-collected isolates of Phytophthora cactorum are sensitive to zoxamide (0.02-1.0 mg/L; 6 days), with a mean EC50 value of 0.14 mg/L for inhibiting radial mycelial growth[1].
Zoxamide (0-1 ppm) rapidly and potently inhibits nuclear division in Phytophthora capsici seedlings[2].
Zoxamide (0.05 ppm; 30 min) completely disrupts the microtubule cytoskeleton in germ tubes of *Phytophthora capsici*, eliminating detectable microtubule filaments[2].
Zoxamide (5-30 μM; 1-8 h) inhibits in vitro microtubule assembly of tubulin isolated from bovine brain in a dose-dependent manner, and its inhibitory potency increases with prolonged pre-incubation time[2].
Zoxamide (16 h) potently inhibits the mycelial growth of *Phytophthora capsici* in microtiter plate assays, with an EC50 of 0.0031 ppm[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 156052-68-5
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Appearance Solid
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Molecular Weight 336.64
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Formel C14H16Cl3NO2
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Color White to off-white
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SMILES
O=C(NC(C)(CC)C(CCl)=O)C1=CC(Cl)=C(C)C(Cl)=C1
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Synonyms
RH-7281
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (267 KB)
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SDS (537 KB)
- English - EN (537 KB)
- Français - FR (537 KB)
- Deutsch - DE (537 KB)
- Norwegian - NO (537 KB)
- Español - ES (537 KB)
- Swedish - SV (537 KB)
- Italian - IT (537 KB)
- Korean - KR (537 KB)
- Portuguese - PT (537 KB)
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Handling Instructions (2659 KB)
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Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Zoxamide Related Classifications
HY-120921 Related Classifications
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