Anticancer agent 94
Anticancer agent 94 is a 4-Hydroxycoumarin derivative. Anticancer agent 94 can inhibit invasion and migration of lung cancer cells by modulating expression of epithelial-mesenchymal transition (EMT) effectors.
For research use only. We do not sell to patients.
- Formula: C22H15NO4
- Molecular Weight:357.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Anticancer agent 94 (compound 4i) (5-15 μM; 24 h) significantly inhibits A549 cell invasion by ~ 40%[1].
Anticancer agent 94 (15 μM; 24-72 h) significantly inhibits A549 cell migration[1].
Anticancer agent 94 (5-15 μM; 4 h) inhibits lung cancer cell motility by downregulating EMT markers[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells
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Concentration:5, 10, 15 μM
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Incubation Time:24 hours
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Result:Significantly increased the expression of E-cadherin.
Downregulated the expression of N-cadherin.
Chemical Information
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Molecular Weight 357.36
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Formula C22H15NO4
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SMILES
O=C(C1=CC=C(C2=CC=CC=C2)C=C1)NC(C3=O)=C(O)C4=C(O3)C=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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