EG36
EG36 is a selective E. coli DnaK inhibitor that inhibits DnaK ATPase activity at a concentration of 100 μM. EG36 directly binds to the nucleotide-binding domain (NBD) of E. coli DnaK by disrupting the DnaK-DnaJ interaction. EG36 can be used for research on bacterial infectious diseases.
For research use only. We do not sell to patients.
- CAS No.: 2215779-34-1
- Formula: C37H41FN4O4
- Molecular Weight:624.74
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
HSP70 |
EG36 (50-200 μM) inhibits DnaJ-GrpE-stimulated ATPase activity of purified E. coli DnaK in a dose-dependent manner, with measurable inhibition at 50, 100, and 200 μM, and enhanced inhibition with increasing DnaJ concentrations[1].
EG36 directly binds to the isolated nucleotide-binding domain of E. coli DnaK and inhibits its inherent ATPase activity[1].
EG36 does not act as a general Hsp inhibitor, as it does not alter the ATPase activity or thermal stability of bacterial HtpG[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2215779-34-1
-
Molecular Weight 624.74
-
Formula C37H41FN4O4
-
SMILES
COC1=CC=CC=C1N2CCC(CN3CCOC4=C(CC5=CC(C(N(CC3)C)=O)=CC=C5)C=C(C=C4)C6=CN=C(C=C6)F)(CC2)O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EG36 Related Classifications
HY-181810 Related Classifications
Powered by Bioz