BSG - basigin (Ok blood group) Gene
Also Known as OK; 5F7; TCSF; CD147; EMPRIN; HAb18G; EMMPRIN
Species: Homo sapiens
About BSG
This gene has 21 transcripts (splice variants), 208 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in heart (RPKM 230.6), colon (RPKM 194.1) and 25 other tissues.
Summary
The protein encoded by this gene, basigin, is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. Basigin is also a member of the immunoglobulin superfamily, ubiquitously expressed in various tissues. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020]
BSG Products (5)
| mRNA | Protein | Name |
|---|---|---|
| NM_001322243.2 | NP_001309172.1 | basigin isoform 2 precursor |
| NM_001728.4 | NP_001719.2 | basigin isoform 1 precursor |
| NM_198589.3 | NP_940991.1 | basigin isoform 2 precursor |
| NM_198590.3 | NP_940992.1 | basigin isoform 3 |
| NM_198591.4 | NP_940993.2 | basigin isoform 3 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
11353871 | GOA |
| enables signaling receptor activity |
IDA
IDA: Inferred from direct assay
|
11688976 | GOA |
| enables virus receptor activity |
IMP
IMP: Inferred from mutant phenotype
|
20147391 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in endoplasmic reticulum membrane |
IDA
IDA: Inferred from direct assay
|
15688292 | GOA |
| located in endosome |
IDA
IDA: Inferred from direct assay
|
29739904 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
11992541 | GOA |
BSG Protein Structure
I-set: Immunoglobulin I-set domain (25 - 113)
Ig_2: Immunoglobulin domain (135 - 204)
I-set: Immunoglobulin I-set domain (224 - 318)
- 0
- 100
- 200
- 300
- 385 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
basigin |
|
BSG Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Cross
|
BSG | P35613 | S | SARS-CoV-2 | P0DTC2 | 33277466 | |
|
Cross
|
BSG | P35613 | S | SARS-CoV-2 | P0DTC2 | 33277466 | |
|
Cross
|
BSG | P35613 | S | SARS-CoV-2 | P0DTC2 | 33277466 | |
|
Cross
|
BSG | P35613 | S | SARS-CoV-2 | P0DTC2 | 33277466 | |
|
Cross
|
BSG | P35613 | S | SARS-CoV-2 | P0DTC2 | 33277466 | |
|
Intra
|
BSG | P35613 | P49768-PRO_0000025592 | Homo sapiens | P49768-PRO_0000025592 | 15890777 | |
|
Intra
|
BSG | P35613 | P49768-PRO_0000025592 | Homo sapiens | P49768-PRO_0000025592 | 15890777 | |
|
Intra
|
BSG | P35613 | PPIA | Homo sapiens | P62937 | 11353871 | |
|
Intra
|
BSG | P35613 | NCSTN | Homo sapiens | Q92542 | 15890777 | |
|
Intra
|
BSG | P35613 | NCSTN | Homo sapiens | Q92542 | 15890777 |
Recombinant BSG Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P70029 | Basigin/CD147 Protein, Human (HEK293, His) | P35613-2 (A22-H205) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P72350 | Basigin/CD147 Protein, Human (Biotinylated, HEK293, Avi-His) | P35613-2 (A22-H205) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P74387 | Basigin/CD147 Protein, Human (HEK293, Fc) | P35613-2/NP_940991.1 (A22-H205) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P74388 | Basigin/CD147 Protein, Human (HEK293) | P35613-2 (A22-H205) | ≥ 95%, as determined by reducing SDS-PAGE. |
BSG Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P83689 | CD147 Antibody (YA3422) | WB, IHC-P, IHC-F, ICC/IF | Human |
| HY-P83689A | CD147 Antibody (YA3422)(PBS only) | WB, IHC-P, IHC-F, ICC/IF | Human |
| HY-P84277 | CD147 Antibody (YA3974) | IHC-P, ICC/IF, FC, ELISA | Human |
| HY-P84277A | CD147 Antibody (YA3974)(PBS only) | IHC-P, ICC/IF, FC, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Severe Acute Respiratory Syndrome |
|
|
| Ameloblastoma |
|
|
| Measles |
|
|
| Lymphopenia |
|
|
| Anaplastic Large Cell Lymphoma |
|
|
| Reactive Arthritis |
|
|
| Conjunctival Vascular Disease |
|
|
| Transitional Cell Carcinoma |
|
|
| Keratoconjunctivitis |
|
|
| Newcastle Disease |
|
|
| Cervical Squamous Cell Carcinoma |
|
|
| Bladder Cancer |
|
|
| Malaria |
|
|
| Ovarian Cancer |
|
|
| Melanoma |
|
|
| Adult Teratoma |
|
|
| Anaplastic Astrocytoma |
|
|
| Long Covid |
|
|
| Lung Cancer |
|
|
| Coronavirus Infectious Disease |
|
|
| Breast Cancer |
|
|
| Rheumatoid Arthritis |
|
|
| Pancreatic Cancer |
|
|
| Laryngeal Squamous Cell Carcinoma |
|
|
| Marfan Syndrome |
|
|
| Gastric Cancer |
|
|
| Colorectal Cancer |
|
|
| Hepatocellular Carcinoma |
|
|
| Heart Disease |
|
|
| Testicular Fibroma |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Dilated Cardiomyopathy |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | BSG | VGNC | VGNC:54577 |
| Felis catus | BSG | VGNC | VGNC:69362 |
| Rattus norvegicus | BSG | RGD | RGD:2220 |
| Mus musculus | BSG | MGD | MGI:88208 |
| Bos taurus | BSG | VGNC | VGNC:52220 |
| Macaca mulatta | BSG | VGNC | VGNC:108480 |
| Others | BSG | NCBI |