NSC 15364
Based on 10 publication(s) in Google Scholar
NSC 15364 is an inhibitor of VDAC1 oligomerization and apoptosis.
For research use only. We do not sell to patients.
- Purity: 99.88%
- CAS No.: 4550-72-5
- Formula: C13H14N4O
- Molecular Weight:242.28
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Anti-Cardiovascular Disease Compound Library
HY-L046
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Targeted Diversity Library
HY-L099
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Mitochondrial Protection Compound Library
HY-L144
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Highly Selective Inhibitors Library
HY-L158
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Cell Death Library
HY-L162
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Ion Channel Compound Library
HY-L166
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
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Apoptosis Compound Library
HY-L003
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Membrane Transporter/Ion Channel Compound Library
HY-L011
Publications Citing Use of MedChemExpress (MCE) NSC 15364
More- Adv Sci (Weinh). 2023 Mar;10(7):e2203869. [Abstract]
- Cardiovasc Res. 2023 Oct 24;119(13):2342-2354. [Abstract]
- Cell Death Dis. 2024 Nov 9;15(11):811. [Abstract]
- Cell Death Dis. 2023 May 13;14(5):325. [Abstract]
- Cell Death Discov. 2023 Aug 15;9(1):297. [Abstract]
- Free Radic Biol Med. 2026 Jul 8:254:690-700. [Abstract]
- Cell Rep. 2024 Apr 23;43(4):114088. [Abstract]
- J Ethnopharmacol. 2025 Jul 24:351:120147. [Abstract]
- mBio. 2023 Dec 19;14(6):e0265123. [Abstract]
- SSRN. 2025 Dec 15.
Biological Activity
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VDAC1 |
Chemical Information
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CAS No. 4550-72-5
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Appearance Solid
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Molecular Weight 242.28
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Formula C13H14N4O
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Color Gray to brown
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SMILES
O=C(NC1=CC=C(N)C=C1)NC2=CC=C(N)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (10)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
MCU Upregulation Overactivates Mitophagy by Promoting VDAC1 Dimerization and Ubiquitination in the Hepatotoxicity of Cadmium. [Abstract]2023 Mar;10(7):e2203869. PMID: 36642847 -
Cardiovasc Res
2023 Oct 24;119(13):2342-2354. PMID: 37556386 -
Cell Death Dis
Inhibition of VDAC1 oligomerization blocks cysteine deprivation-induced ferroptosis via mitochondrial ROS suppression. [Abstract]2024 Nov 9;15(11):811. PMID: 39521767 -
Cell Death Dis
Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats. [Abstract]2023 May 13;14(5):325. PMID: 37179386 -
Cell Death Discov
NeuroD4 converts glioblastoma cells into neuron-like cells through the SLC7A11-GSH-GPX4 antioxidant axis. [Abstract]2023 Aug 15;9(1):297. PMID: 37582760 -
Free Radic Biol Med
Polystyrene nanoplastics exacerbated the toxicity of cadmium: from the perspective of the placenta-uterus micro-environment. [Abstract]2026 Jul 8:254:690-700. PMID: 42419651 -
Cell Rep
IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling. [Abstract]2024 Apr 23;43(4):114088. PMID: 38602878 -
J Ethnopharmacol
Harpagide from radix scrophulariae attenuated ischemic stroke injury through calcium homeostasis regulation between mitochondria-associated membranes via the IP3R1/GRP75/VDAC1 complex. [Abstract]2025 Jul 24:351:120147. PMID: 40517916 -
mBio
The glycoprotein 5 of porcine reproductive and respiratory syndrome virus stimulates mitochondrial ROS to facilitate viral replication. [Abstract]2023 Dec 19;14(6):e0265123. PMID: 38047681 -
Solvent & Solubility
DMSO : 50 mg/mL (206.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (10.32 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (8.59 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (477 KB)
- English - EN (477 KB)
- Français - FR (477 KB)
- Deutsch - DE (477 KB)
- Norwegian - NO (477 KB)
- Español - ES (477 KB)
- Swedish - SV (477 KB)
- Italian - IT (477 KB)
- Korean - KR (477 KB)
- Portuguese - PT (477 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 4.1275 mL | 20.6373 mL | 41.2746 mL | 103.1864 mL |
| 5 mM | 0.8255 mL | 4.1275 mL | 8.2549 mL | 20.6373 mL | |
| 10 mM | 0.4127 mL | 2.0637 mL | 4.1275 mL | 10.3186 mL | |
| 15 mM | 0.2752 mL | 1.3758 mL | 2.7516 mL | 6.8791 mL | |
| 20 mM | 0.2064 mL | 1.0319 mL | 2.0637 mL | 5.1593 mL | |
| 25 mM | 0.1651 mL | 0.8255 mL | 1.6510 mL | 4.1275 mL | |
| 30 mM | 0.1376 mL | 0.6879 mL | 1.3758 mL | 3.4395 mL | |
| 40 mM | 0.1032 mL | 0.5159 mL | 1.0319 mL | 2.5797 mL | |
| 50 mM | 0.0825 mL | 0.4127 mL | 0.8255 mL | 2.0637 mL | |
| 60 mM | 0.0688 mL | 0.3440 mL | 0.6879 mL | 1.7198 mL | |
| 80 mM | 0.0516 mL | 0.2580 mL | 0.5159 mL | 1.2898 mL | |
| 100 mM | 0.0413 mL | 0.2064 mL | 0.4127 mL | 1.0319 mL |
NSC 15364 Related Classifications
HY-108937 Related Classifications
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