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Cat. No.: HY-120264

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YPC-22026

YPC-22026 is a zinc-finger protein 143 (ZNF143) inhibitor with an IC₅₀ value of 9.0 μM. YPC-22026 is a potent tumor regression inducer. YPC-22026 exhibits anti‐tumor activities.

For research use only. We do not sell to patients.

CAS No.: 1964457-41-7
Formula: C₁₆H₈F₃N₃O₂
Molecular Weight:331.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

YPC-22026 Chemical Structure

CAS No.: 1964457-41-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

YPC-22026 is a zinc-finger protein 143 (ZNF143) inhibitor with an IC₅₀ value of 9.0 μM. YPC-22026 is a potent tumor regression inducer. YPC-22026 exhibits anti‐tumor activities^[1].

In Vitro

YPC‐22026 (96 h) shows cytotoxic to HCT116 and PC‐3 with IC₅₀ values of 0.33 μM and 0.66 μM, respectively^[1].
YPC‐22026 (3 μM; 24 h) induces G2/M arrest and decreases the binding of ZNF143 to the STAF binding site^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

HCT116 cells
Concentration:

3 μM
Incubation Time:

24 h
Result:

Induced G2/M arrest.

In Vivo

YPC‐22026 (50-100 mg/kg; i.p; on days 1, 2, 3, 8, 9, 12, and 16) significantly inhibits the growth of tumors in the HCT116 xenograft model^[1].
In the PC‐3 xenograft model, YPC‐22026 (75 mg/kg; ip) significantly decreases in the intratumoral expression levels of all ZNF143 target genes, RAD51, PLK1, and Survivin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Six‐week‐old male BALB/c nude mice injected with HCT116 cells^[1]
Dosage:

50 mg/kg and 100 mg/kg
Administration:

i.p; on days 1, 2, 3, 8, 9, 12, and 16 (50 mg/kg ); on days 1, 2, 3, 12, and 16 (100 mg/kg)
Result:

Significantly inhibited the growth of tumors.

Chemical Information

CAS No. 1964457-41-7
Molecular Weight 331.25
Formula C₁₆H₈F₃N₃O₂
SMILES

FC(F)(F)OC1=CC=CC=C1C2=NN=C(C#CC3=CC=CN=C3)O2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hirotaka Haibara, et al. YPC-21661 and YPC-22026, novel small molecules, inhibit ZNF143 activity in vitro and in vivo. Cancer Sci. 2017 May;108(5):1042-1048. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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