(1α,1'S,4β)-Lanabecestat
Based on 1 Customer Validation
(1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) a less active enantiomer of Lanabecestat. Lanabecestat is a potent, orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4 nM.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 96.01%
- CAS No.: 1384082-96-5
- Formule: C26H28N4O
- Masse moléculaire:412.53
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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HY-16759
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HY-10472
LY2811376BACE1 Inhibitor -
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AZD3839 free baseBACE1 Iinhibitor -
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ElenbecestatBACE-1 Inhibitor -
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BCACu(I) Chelator -
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Verubecestat TFABACE1/2 Inhibitor -
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BACE1-IN-1BACE1/2 Inhibitor -
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β-Secretase Inhibitor IV (Standard)BACE-1 Inhibitor -
HY-13240A
LY2886721 hydrochlorideBACE1 Inhibitor
Activité biologique
Description
IC50 & Target
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BACE1 |
Chemical Information
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CAS No. 1384082-96-5
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Appearance Solid
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Masse moléculaire 412.53
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Formule C26H28N4O
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Color Light yellow to khaki
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SMILES
NC(C(C)=N1)=N[C@]21C3=C(C=CC(C4=CC(C#CC)=CN=C4)=C3)C[C@]52CC[C@@H](OC)CC5
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Synonyms
(1α,1'S,4β)-AZD3293; (1α,1'S,4β)-LY3314814
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvant et solubilité
In Vitro:
DMSO : 250 mg/mL (606.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.17 mg/mL (5.26 mM); Clear solution
This protocol yields a clear solution of ≥ 2.17 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.4241 mL | 12.1203 mL | 24.2407 mL | 60.6017 mL |
| 5 mM | 0.4848 mL | 2.4241 mL | 4.8481 mL | 12.1203 mL | |
| 10 mM | 0.2424 mL | 1.2120 mL | 2.4241 mL | 6.0602 mL | |
| 15 mM | 0.1616 mL | 0.8080 mL | 1.6160 mL | 4.0401 mL | |
| 20 mM | 0.1212 mL | 0.6060 mL | 1.2120 mL | 3.0301 mL | |
| 25 mM | 0.0970 mL | 0.4848 mL | 0.9696 mL | 2.4241 mL | |
| 30 mM | 0.0808 mL | 0.4040 mL | 0.8080 mL | 2.0201 mL | |
| 40 mM | 0.0606 mL | 0.3030 mL | 0.6060 mL | 1.5150 mL | |
| 50 mM | 0.0485 mL | 0.2424 mL | 0.4848 mL | 1.2120 mL | |
| 60 mM | 0.0404 mL | 0.2020 mL | 0.4040 mL | 1.0100 mL | |
| 80 mM | 0.0303 mL | 0.1515 mL | 0.3030 mL | 0.7575 mL | |
| 100 mM | 0.0242 mL | 0.1212 mL | 0.2424 mL | 0.6060 mL |
(1α,1'S,4β)-Lanabecestat Related Classifications
HY-100740C Related Classifications
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