Cynarin
Based on 6 publication(s) in Google Scholar
Cynarin is an antichoke agent with a variety of biological activities including antioxidant, antihistamic and antiviral activities.
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- Pureté: 99.80%
- CAS No.: 30964-13-7
- Formule: C25H24O12
- Masse moléculaire:516.45
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Publications Citing Use of MedChemExpress (MCE) Cynarin
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Cell Proliferation/Viability Assay
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WB
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RT-PCR
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IF
Activité biologique
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Cell Line
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Type | Value | Description | References |
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| MT2 | ED50 |
4 μM
Compound: 1,5-DCQA
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Concentration that inhibits Human Immunodeficiency Virus Type 1 (HIV-1)-induced death of MT-2 cells
Concentration that inhibits Human Immunodeficiency Virus Type 1 (HIV-1)-induced death of MT-2 cells
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[PMID: 9986720] |
Cynarin inhibits taste receptors, making water to be sweet. It has been shown to have some pharmacological properties including hypocholesterolemic, hepatoprotective, antiviral, antibacterial, and antihistamic effects. Cynarin has marked antioxidant, anticholinergic, reducing ability, radical-scavenging, and metal-binding activities. Cynarin demonstrates 87.72% inhibition of linoleic acid lipid peroxidation at 30 mg/mL concentration. Cynarin exhibits effective DMPD+, ABTS+, O2-, DPPH1, and H2O2 scavenging effects, reducing capabilities and Fe2+ chelating effects. IC50 and Ki of cynarin for acetylcholinesterase enzyme inhibition are 243.67nM and 39.34±13.88 nM, respectively[1]. Cynarin is a potential immunosuppressant that blocks the interaction between the CD28 of T-cell receptor and CD80 of antigen presenting cells. Cynarin blocks about 87% of the CD28-dependent "signal 2" pathway of T-cell activation under the condition of one to one ratio of T-cell and B-cell. Cynarin binds to the "G-pocket" of CD28 and thus interrupts the site of interaction between CD28 and CD80[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 30964-13-7
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Appearance Solid
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Masse moléculaire 516.45
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Formule C25H24O12
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Color White to light yellow
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SMILES
O=C([C@]1(OC(/C=C/C2=CC=C(O)C(O)=C2)=O)C[C@@H](OC(/C=C/C3=CC=C(O)C(O)=C3)=O)[C@@H](O)[C@H](O)C1)O
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Synonyms
Cynarine
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (6)
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Journal Impact Factor
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Most Recent
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Autophagy
XIAP-ULK1-Mediated mitophagy modulates carnitine metabolism to mitigate diabetic kidney disease. [Abstract]2025 Oct 25. PMID: 41139215 -
Food Funct
Cynarin alleviates apical periodontitis by inhibiting macrophage M1 polarization via the PGC1α/ROS signaling axis. [Abstract]2026 Jun 22;17(12):5378-5393. PMID: 42132631 -
Food Funct
Cynarin alleviates acetaminophen-induced acute liver injury through the activation of Keap1/Nrf2-mediated lipid peroxidation defense via the AMPK/SIRT3 signaling pathway. [Abstract]2024 May 7;15(9):4954-4969. PMID: 38602356 -
Inflamm Res
Cynarin inhibits microglia-induced pyroptosis and neuroinflammation via Nrf2/ROS/NLRP3 axis after spinal cord injury. [Abstract]2024 Nov;73(11):1981-1994. PMID: 39340662 -
Anim Cells Syst
Cynarin attenuates LPS-induced endothelial inflammation via upregulation of the negative regulator MKP-3. [Abstract]2022 May 20;26(3):119-128. PMID: 35784390
Cynarin purchased from MedChemExpress. Usage Cited in: Anim Cells Syst. 2022 May 20;26(3):119-128. [Abstract]
Cell viability of EA.hy926 cells after treatment with different Cynarin (1, 2, 5, 10 μM) concentrations as determined using the cell counting kit-8 assay.
Cynarin purchased from MedChemExpress. Usage Cited in: Anim Cells Syst. 2022 May 20;26(3):119-128. [Abstract]
EA.hy926 cells were treated with Cynarin (1, 2, 5 μM) for 4 h before adding LPS (1 μg/mL) for another 24 h. VCAM-1 expression level was measured via western blotting.
Cynarin purchased from MedChemExpress. Usage Cited in: Anim Cells Syst. 2022 May 20;26(3):119-128. [Abstract]
The mRNA expression levels of inflammatory genes [monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor (TNF-α), and interleukin (IL)−1β] as detected via real-time PCR treated with Cynarin (1, 5 μM).
Cynarin purchased from MedChemExpress. Usage Cited in: Anim Cells Syst. 2022 May 20;26(3):119-128. [Abstract]
The cells were treated with Cynarin (5 µM) for 1 h before adding LPS (1 μg/mL) for another 30 min. Representative immunofluorescence staining images showing NF-κB p65 (green) and the nucleus (blue).
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Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607
Solvant et solubilité
DMSO : 250 mg/mL (484.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocole
The cytotoxicity of cynarin treatment of T-cells is measured by MTT colorimetric assay. 100 μL Jurkat cells are incubated with cynarin (0-1000 μg/mL) for 24 h at 37°C. The cell solution is then centrifuged and the supernatant removed. 200 μL of MTT is added and the cell solution is incubated again for 4 h at 37°C. 200 μL of DMSO lysis buffer is added into the cell medium and the concentration of dissolved MTT crystals is measured by plate reader at 560 nm[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pureté et documentation
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Fiche technique (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Topal M, et al. Antioxidant, antiradical, and anticholinergic properties of cynarin purified from the Illyrian thistle (Onopordum illyricum L.). J Enzyme Inhib Med Chem. 2016;31(2):266-75. [Content Brief]
[2]. Dong GC, et al. Blocking effect of an immuno-suppressive agent, cynarin, on CD28 of T-cell receptor. Pharm Res. 2009 Feb;26(2):375-81. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.9363 mL | 9.6815 mL | 19.3630 mL | 48.4074 mL |
| 5 mM | 0.3873 mL | 1.9363 mL | 3.8726 mL | 9.6815 mL | |
| 10 mM | 0.1936 mL | 0.9681 mL | 1.9363 mL | 4.8407 mL | |
| 15 mM | 0.1291 mL | 0.6454 mL | 1.2909 mL | 3.2272 mL | |
| 20 mM | 0.0968 mL | 0.4841 mL | 0.9681 mL | 2.4204 mL | |
| 25 mM | 0.0775 mL | 0.3873 mL | 0.7745 mL | 1.9363 mL | |
| 30 mM | 0.0645 mL | 0.3227 mL | 0.6454 mL | 1.6136 mL | |
| 40 mM | 0.0484 mL | 0.2420 mL | 0.4841 mL | 1.2102 mL | |
| 50 mM | 0.0387 mL | 0.1936 mL | 0.3873 mL | 0.9681 mL | |
| 60 mM | 0.0323 mL | 0.1614 mL | 0.3227 mL | 0.8068 mL | |
| 80 mM | 0.0242 mL | 0.1210 mL | 0.2420 mL | 0.6051 mL | |
| 100 mM | 0.0194 mL | 0.0968 mL | 0.1936 mL | 0.4841 mL |
Cynarin Related Classifications
HY-N0359 Related Classifications
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