Fluorothyl
Based on 1 Customer Validation
Fluorothyl (Bis (2,2,2-trifluoroethyl) ether; Flurothyl) is a GABAA receptor modulator and epileptogenic agent. Fluorothyl induces generalized epilepsy in mice. Fluorothyl is used for epilepsy research.
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- Pureté: 98.0%
- CAS No.: 333-36-8
- Formule: C4H4F6O
- Masse moléculaire:182.06
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:mixed 129S5.C57BL/6 background (8 to 12 weeks old, both male and female littermates)[1]
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Dosage:20 μL/min
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Administration:inhalation via sealed chamber; continuous
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Result:Reduced average latency to generalized tonic-clonic seizure (GTCS) to 124 seconds in heterozygous Pcdh19+/- female mice, compared to 177 seconds in wild-type female mice.
Reduced average latency to GTCS to 114 seconds in knockout Pcdh19-/- female mice, compared to 177 seconds in wild-type female mice.
Showed comparable average latencies to first myoclonic jerk across all female genotypes.
Demonstrated no statistically significant difference in average latency to GTCS between hemizygous Pcdh19-/y male mice (123 seconds) and wild-type male mice (139 seconds).
Showed comparable average latencies to first myoclonic jerk across all male genotypes.
Chemical Information
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CAS No. 333-36-8
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Appearance Liquid (Density: 1.404 g/cm3 )
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Masse moléculaire 182.06
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Formule C4H4F6O
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Color Colorless to light yellow
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SMILES
FC(F)(F)COCC(F)(F)F
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Synonyms
Bis(2,2,2-trifluoroethyl) ether; Flurothyl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
DMSO : ≥ 125 mg/mL (686.59 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (549.27 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (11.42 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureté et documentation
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Fiche technique (270 KB)
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SDS (605 KB)
- English - EN (605 KB)
- Français - FR (605 KB)
- Deutsch - DE (605 KB)
- Norwegian - NO (605 KB)
- Español - ES (605 KB)
- Swedish - SV (605 KB)
- Italian - IT (605 KB)
- Korean - KR (605 KB)
- Portuguese - PT (605 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 5.4927 mL | 27.4635 mL | 54.9269 mL | 137.3174 mL |
| 5 mM | 1.0985 mL | 5.4927 mL | 10.9854 mL | 27.4635 mL | |
| 10 mM | 0.5493 mL | 2.7463 mL | 5.4927 mL | 13.7317 mL | |
| 15 mM | 0.3662 mL | 1.8309 mL | 3.6618 mL | 9.1545 mL | |
| 20 mM | 0.2746 mL | 1.3732 mL | 2.7463 mL | 6.8659 mL | |
| 25 mM | 0.2197 mL | 1.0985 mL | 2.1971 mL | 5.4927 mL | |
| 30 mM | 0.1831 mL | 0.9154 mL | 1.8309 mL | 4.5772 mL | |
| 40 mM | 0.1373 mL | 0.6866 mL | 1.3732 mL | 3.4329 mL | |
| 50 mM | 0.1099 mL | 0.5493 mL | 1.0985 mL | 2.7463 mL | |
| 60 mM | 0.0915 mL | 0.4577 mL | 0.9154 mL | 2.2886 mL | |
| 80 mM | 0.0687 mL | 0.3433 mL | 0.6866 mL | 1.7165 mL | |
| 100 mM | 0.0549 mL | 0.2746 mL | 0.5493 mL | 1.3732 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Fluorothyl Related Classifications
HY-B1112 Related Classifications
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- Fluorothyl
- 333-36-8
- Bis(2,2,2-trifluoroethyl) ether
- Flurothyl
- GABA Receptor
- generalized seizures
- generalized tonic-clonic seizures
- pcdh19-related epilepsy
- myoclonic jerks
- mice
- anesthetic ethers-binding site
- knockout Pcdh19 female mice
- heterozygous Pcdh19 female mice
- epilepsy
- GABAA receptor
- Inhibitor
- inhibitor
- inhibit