G-744
G-744 is a highly potent, selective and orally active Btk inhibitor with an IC50 of 2 nM. G-744 is metabolically stable, well tolerated and efficacious to treat arthritis.
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- CAS No.: 1346669-54-2
- Formule: C29H29N5O3S
- Masse moléculaire:527.64
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC50: 2 nM (Btk), 64 nM (CD86)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Lewis rat based CIA models[1].
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Dosage:6.25, 12.25, 25 mg/kg.
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Administration:Orally, b.i.d., daily for 17 days.
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Result:All three doses resulted in a significant dose-dependent inhibition of ankle thickness between day 10 and day 17 (onset of increase in ankle diameter on day 9).
Chemical Information
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CAS No. 1346669-54-2
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Masse moléculaire 527.64
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Formule C29H29N5O3S
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SMILES
CN(C1=O)C=C(C2=CC=CC(N3C(C(SC4=C5CC(C)(C)C4)=C5CC3)=O)=C2CO)C=C1NC6=CC=NC=N6
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
G-744 Related Classifications
HY-102036 Related Classifications
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