MMAD
Based on 1 Customer Validation
MMAD is a potent tubulin inhibitor, is a toxin payload in antibody agent conjugates (ADCs).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.94%
- CAS No.: 203849-91-6
- Formule: C41H66N6O6S
- Masse moléculaire:771.06
-
Stockage:
4°C, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Pureté et documentation
- Références
-
Help & FAQs
-
HY-15162
Monomethyl auristatin E
-
HY-15579
MMAF
-
HY-B0015
Paclitaxel
-
HY-15580
Dolastatin 10
-
HY-16700
PNU-159682
-
HY-12522
PF-06380101
-
HY-15142
Doxorubicin hydrochloride
-
HY-13442
Eribulin
-
HY-15162R
Monomethyl auristatin E (Standard)
-
HY-13631D
DXd
-
HY-19792
Mertansine
-
HY-15162G
Monomethyl auristatin E (GMP)
Voir tous les produits spécifiques à Isoform ADC Payloads
More
Activité biologique
|
Auristatin |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BT-474 | GI50 |
0.12 nM
Compound: 2, MMAD
|
Cytotoxicity against human BT474 cells assessed as cell viability incubated fore 4 days by MTS assay
Cytotoxicity against human BT474 cells assessed as cell viability incubated fore 4 days by MTS assay
|
[PMID: 25431858] |
| MDA-MB-361 | GI50 |
0.09 nM
Compound: 2, MMAD
|
Cytotoxicity against human MDA-MB-361 cells assessed as cell viability incubated fore 4 days by MTS assay
Cytotoxicity against human MDA-MB-361 cells assessed as cell viability incubated fore 4 days by MTS assay
|
[PMID: 25431858] |
| NCI-N87 | GI50 |
0.3 nM
Compound: 2, MMAD
|
Cytotoxicity against human NCI-N87 cells assessed as cell viability incubated fore 4 days by MTS assay
Cytotoxicity against human NCI-N87 cells assessed as cell viability incubated fore 4 days by MTS assay
|
[PMID: 25431858] |
MMAD (Monomethyl Dolastatin 10) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. When compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction, site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 203849-91-6
-
Appearance Solid
-
Masse moléculaire 771.06
-
Formule C41H66N6O6S
-
Color White to off-white
-
SMILES
O=C([C@H](C)[C@H]([C@]1([H])CCCN1C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C([C@@H](NC([C@@H](N(C)[H])C(C)C)=O)C(C)C)=O)C)=O)OC)N[C@@H](CC2=CC=CC=C2)C3=NC=CS3
-
Synonyms
Demethyldolastatin 10; Monomethylauristatin D; Monomethyl Dolastatin 10
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
4°C, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
Solvant et solubilité
DMSO : ≥ 100 mg/mL (129.69 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
-
Fiche technique (274 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2969 mL | 6.4846 mL | 12.9692 mL | 32.4229 mL |
| 5 mM | 0.2594 mL | 1.2969 mL | 2.5938 mL | 6.4846 mL | |
| 10 mM | 0.1297 mL | 0.6485 mL | 1.2969 mL | 3.2423 mL | |
| 15 mM | 0.0865 mL | 0.4323 mL | 0.8646 mL | 2.1615 mL | |
| 20 mM | 0.0648 mL | 0.3242 mL | 0.6485 mL | 1.6211 mL | |
| 25 mM | 0.0519 mL | 0.2594 mL | 0.5188 mL | 1.2969 mL | |
| 30 mM | 0.0432 mL | 0.2162 mL | 0.4323 mL | 1.0808 mL | |
| 40 mM | 0.0324 mL | 0.1621 mL | 0.3242 mL | 0.8106 mL | |
| 50 mM | 0.0259 mL | 0.1297 mL | 0.2594 mL | 0.6485 mL | |
| 60 mM | 0.0216 mL | 0.1081 mL | 0.2162 mL | 0.5404 mL | |
| 80 mM | 0.0162 mL | 0.0811 mL | 0.1621 mL | 0.4053 mL | |
| 100 mM | 0.0130 mL | 0.0648 mL | 0.1297 mL | 0.3242 mL |
MMAD Related Classifications
HY-15581 Related Classifications
Powered by Bioz