MethADP
Based on 1 Customer Validation
MethADP is a specific CD73 inhibitor.
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- Pureté: 99.0%
- CAS No.: 3768-14-7
- Formule: C11H17N5O9P2
- Masse moléculaire:425.23
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
CD73[1].
MethADP (AMP-CP: 20 μM) causes a marked inhibition of adenosine formation (0.96±0.96 μM) compared to untreated controls (9.6±1.5 μM) in A498 and RT4 cells, and MethADP (100 μM) completely inhibits the adenosine formation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 3768-14-7
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Appearance Solid
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Masse moléculaire 425.23
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Formule C11H17N5O9P2
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Color White to off-white
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SMILES
O[C@@H]1[C@H](O)[C@@H](COP(O)(CP(O)(O)=O)=O)O[C@H]1N2C=NC3=C2N=CN=C3N
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Synonyms
Adenosine 5'-(α,β-methylene)diphosphate
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
H2O : 50 mg/mL (117.58 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (276 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.3517 mL | 11.7583 mL | 23.5167 mL | 58.7917 mL |
| 5 mM | 0.4703 mL | 2.3517 mL | 4.7033 mL | 11.7583 mL | |
| 10 mM | 0.2352 mL | 1.1758 mL | 2.3517 mL | 5.8792 mL | |
| 15 mM | 0.1568 mL | 0.7839 mL | 1.5678 mL | 3.9194 mL | |
| 20 mM | 0.1176 mL | 0.5879 mL | 1.1758 mL | 2.9396 mL | |
| 25 mM | 0.0941 mL | 0.4703 mL | 0.9407 mL | 2.3517 mL | |
| 30 mM | 0.0784 mL | 0.3919 mL | 0.7839 mL | 1.9597 mL | |
| 40 mM | 0.0588 mL | 0.2940 mL | 0.5879 mL | 1.4698 mL | |
| 50 mM | 0.0470 mL | 0.2352 mL | 0.4703 mL | 1.1758 mL | |
| 60 mM | 0.0392 mL | 0.1960 mL | 0.3919 mL | 0.9799 mL | |
| 80 mM | 0.0294 mL | 0.1470 mL | 0.2940 mL | 0.7349 mL | |
| 100 mM | 0.0235 mL | 0.1176 mL | 0.2352 mL | 0.5879 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
MethADP Related Classifications
HY-112502 Related Classifications
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