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Cat. No.: HY-P991993

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AB054

AB054 is a humanized monoclonal antibody targeting factor XII (FXII). AB054 inhibits FXII activation and FXIIa activity through specific binding to the catalytic domain of FXII, and exerts antithrombotic effects in a concentration-dependent manner. AB054 can be used in studies related to thrombosis.

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Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AB054 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Species Reactivity
- In Vitro
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Species Reactivity

Human

In Vitro

AB054 (0-100 μg/mL; 5 min) significantly prolongs the aPTT of human plasma and baboon plasma in a concentration-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AB054 (2-5 mg/kg; i.v. bolus; 30 min before experiment) significantly inhibits platelet-dependent thrombosis in baboon membrane oxygenators, and its antithrombotic effect becomes more pronounced when used in combination with Heparin (HY-17567)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Baboons (juvenile male, 9~15kg, with healed surgically implanted chronic arteriovenous shunt device)^[1]
Dosage:

5 mg/kg (single agent); 2 mg/kg (plus 5 mg/kg 24h prior, in combination with 20 U/kg heparin)
Administration:

i.v. bolus; 30 min before experiment (AB054); 15 min before experiment (heparin)
Result:

Reduced platelet deposition rate, terminal platelet deposition, and terminal fibrin content in.
Maintained hemostatic parameters (bleeding time, blood loss, bleeding rate) within normal baboon ranges across all treatment groups.

Gene ID

2161 [NCBI]

Accession

P00748

Target

F12/Factor XII

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

Application

ELISA, FACS, Functional assay

Chemical Information

SMILES

[AB054]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Inhibitory Antibodies User Guide (603 KB)

Références

[1]. Andras Gruber, et al. Therapeutic factor xii antibody. HK40062102A. 2022-06-10.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- Species Reactivity
- In Vitro
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
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MCE Japan Authorized Agent:

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AB054

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

AB054 Related Classifications

HY-P991993 Related Classifications