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Cat. No.: HY-139860

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Anticancer agent 15

Anticancer agent 15 is capable of significantly increasing the cellular level of ROS and inducing melanoma cancer cell death via necroptosis.

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CAS No.: 2710312-73-3
Formule: C₃₅H₄₀Cl₂N₂O₅
Masse moléculaire:639.61

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Anticancer agent 15 Chemical Structure

CAS No.: 2710312-73-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
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Activité biologique

Description

Anticancer agent 15 is capable of significantly increasing the cellular level of ROS and inducing melanoma cancer cell death via necroptosis.

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	5.057 μM Compound: 37	Cytotoxicity against mouse 4T1 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Cytotoxicity against mouse 4T1 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 34704758]
A-375	IC₅₀	4336 μM Compound: 37	Cytotoxicity against human A-375 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Cytotoxicity against human A-375 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 34704758]
B16-F10	IC₅₀	2.901 μM Compound: 37	Cytotoxicity against mouse B16-F10 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Cytotoxicity against mouse B16-F10 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 34704758]
CT26	IC₅₀	8.01 μM Compound: 37	Cytotoxicity against mouse CT26 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Cytotoxicity against mouse CT26 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 34704758]
HCT-116	IC₅₀	3.263 μM Compound: 37	Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 34704758]
Kasumi 1	IC₅₀	1.921 μM Compound: 37	Cytotoxicity against human Kasumi 1 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Cytotoxicity against human Kasumi 1 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 34704758]

Chemical Information

CAS No. 2710312-73-3
Masse moléculaire 639.61
Formule C₃₅H₄₀Cl₂N₂O₅
SMILES

C[C@@H]([C@@H]([C@]1(C)C=C)OC(C2=CC(Cl)=NC(C)=C2)=O)[C@@](CC3=C)(CC[C@H]4C)[C@](C3=O)([H])[C@@]4([C@@H](C1)OC(C5=CC(Cl)=NC(C)=C5)=O)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhang K, et al. A Novel Anticancer Stem Cell Compound Derived from Pleuromutilin Induced Necroptosis of Melanoma Cells. J Med Chem. 2021 Nov 11;64(21):15825-15845. [Content Brief]

Calculators

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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