Antimicrobial agent-5
Antimicrobial agent-5 is an potent antimicrobial agent, and displays excellent cell selectivity against Gram-negative bacteria and Gram-positive bacteria. Antimicrobial agent-5 blocks the interaction between LPS and CD14/TLR4 receptor, and shows anti-inflammatory activity against LPS-induced inflammation.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 2978694-04-9
- Formule: C32H48N16
- Masse moléculaire:656.83
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Antimicrobial agent-5 (compound 9) (0.5-32 μg/mL, 16 h; 1-128 μg/mL; 24 h) shows potent biofilm inhibitory (IC50=2 μg/mL) and eradicating activities (IC50=16 μg/mL) against multidrug-resistant Pseudomonas aeruginosa (MDRPA)[1].
Antimicrobial agent-5 (5 μgmL, 20 μg/mL; 18 h) inhibits both the release and expression of nitric oxide (NO) and tumor necrosis factor-α (TNF-α) from LPS-stimulated (1 μg/mL) RAW 264.7 cells[1].
Antimicrobial agent-5 exhibits proteolytic resistance and salt/serum stability[1].
Antimicrobial agent-5 (0.5-256 μg/mL; 2 h) exhibits negligible side effects against sheep red blood cells (sRBCs) with hemolytic activity (the minimum hemolytic concentration, MHC) of >256 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:RAW264.7 cells
-
Concentration:5 μg/mL, 20 μg/mL
-
Incubation Time:18 hours
-
Result:Decreased TNF-α release at 20 μg/mL, with inhibition rate of 72.44%.
Results reduction in the LPS-stimulated production of NO, with inhibition rate of 31.51%.
-
Cell Line:E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], S. epidermidis [KCTC 1917], S. aureus [KCTC1621]
-
Concentration:1-128 μg/mL
-
Incubation Time:24 hours
-
Result:Inhibited Gram-negative bacteria and Gram-positive bacteria with IC50 of 6.1 μM (E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], S. epidermidis [KCTC 1917], S. aureus [KCTC1621]), respectively.
Chemical Information
-
CAS No. 2978694-04-9
-
Masse moléculaire 656.83
-
Formule C32H48N16
-
SMILES
NCCNC1=NC(NCCN)=NC(N(C(CN2C3=NC(NCCN)=NC(NCCN)=N3)CC4=CC=CC=C4)CC2CC5=CC=CC=C5)=N1
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz