Antimicrobial agent-9
Antimicrobial agent-9 (Compound 16) is an antimicrobial agent with an MIC range of 4-8 μg/mL against gram-positive and gram-negative bacteria. Antimicrobial agent-9 also shows anti-inflammatory activity.
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- CAS No.: 2978694-25-4
- Formule: C43H62N16
- Masse moléculaire:803.06
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Antimicrobial agent-9 (Compound 16) (0-256 μg/mL; 18-24 h) shows antibacterial activity with geometric mean (GM) values of the MICs of 4.5 μg/mL[1].
Antimicrobial agent-9 shows minimum hemolytic concentration (MHC) of >256 μg/mL, the therapeutic index is 113.8[1].
Antimicrobial agent-9 (5 or 20 μg/mL; 18 h) effectively inhibits the release and expression of NO and TNF-α from LPS-stimulated RAW 264.7 cells[1].
Antimicrobial agent-9 is resistant to various physiological salts, human serum, and proteases[1].
Antimicrobial agent-9 exhibits synergistic antimicrobial activity in combination with three conventional antibiotics (Chloramphenicol (HY-B0239), Ciprofloxacin (HY-B0356), and oxacillin) against MDRPA and MRSA, is promising adjuvants in combination with clinically used antibiotics[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], S. epidermidis [KCTC 1917] and S. aureus [KCTC1621]
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Concentration:0-256 μg/mL
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Incubation Time:18-24 h
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Result:Inhibited bacterial growth with MICs of 4, 8, 4 and 2 μg/mL against E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], S. epidermidis [KCTC 1917] and S. aureus [KCTC1621], respectively.
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Cell Line:LPS-stimulated RAW 264.7 macrophages
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Concentration:5 μg/mL (for NO/iNOS) and 20 μg/mL (for TNF-α)
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Incubation Time:18 h
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Result:Effectively inhibited the production and expression of NO and TNF-α from LPS-stimulated RAW 264.7 cells.
Chemical Information
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CAS No. 2978694-25-4
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Masse moléculaire 803.06
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Formule C43H62N16
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SMILES
NCCCN(C1=NC(NCC2=CC=CC=C2)=NC(N3CCN(C4=NC(NCC5=CC=CC=C5)=NC(N(CCCN)CCCN)=N4)C(CC6=CC=CC=C6)C3)=N1)CCCN
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antimicrobial agent-9 Related Classifications
HY-151403 Related Classifications
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