AP14145
AP14145 is an inhibitor for small conductance calcium-activated potassium channel, inhibits KCa2.2 channel and KCa channel with IC50 of 1.1 μM and 1.1 μM. AP14145 prolongs atrial effective refractory period (AERP) in rats, causes the conversion of atrial fibrillation to sinus rhythum in porcine left ventricular dysfunction models, and exhibits antiarrhythmic effect.
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- CAS No.: 1446770-54-2
- Formule: C18H17F3N4O
- Masse moléculaire:362.35
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Chemical Information
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CAS No. 1446770-54-2
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Masse moléculaire 362.35
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Formule C18H17F3N4O
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SMILES
CC(NC1=C2C(N=C(N[C@@H](C3=CC=CC(C(F)(F)F)=C3)C)N2)=CC=C1)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Citerni C, et al., Inhibition of KCa2 and Kv11.1 Channels in Pigs With Left Ventricular Dysfunction. Front Pharmacol. 2020 May 6;11:556. [Content Brief]
[2]. Simó-Vicens R, et al., A new negative allosteric modulator, AP14145, for the study of small conductance calcium-activated potassium (KCa 2) channels. Br J Pharmacol. 2017 Dec;174(23):4396-4408. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AP14145 Related Classifications
HY-120355 Related Classifications
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