Apoptosis inducer 41
Apoptosis inducer 41 is an apoptosis inducer that induces apoptosis through the mitochondrial pathway. Apoptosis inducer 41 exhibits remarkable inhibitory effects against MCF-7 cells (IC50 = 6.2 μM). Apoptosis inducer 41 significantly arrests MCF-7 cells in the G2/M phase, increases ROS accumulation, induces mitochondrial membrane potential depolarization. Apoptosis inducer 41 can used for the study of breast cancer.
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- CAS No.: 3085940-57-1
- Formule: C39H53BrN4O4
- Masse moléculaire:721.77
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Activité biologique
Description
In Vitro
Apoptosis inducer 41 (Compound 6j) (1‑100 μM, 48 h) exhibits antiproliferative activities in various cells with IC50s of 7.1, 40.9, 6.2 and 46.1 against MDA-MB-231, MDA-MB-468, MCF-7 and MCF-10A cells[1].
Apoptosis inducer 41 (1-9 μM, 24-48 h) significantly induces MCF-7 apoptosis through the mitochondrial apoptosis pathway and arrests cells in the G2/M phase[1].
Apoptosis inducer 41 (1-9 μM, 24 h) induces ROS generation and impaires mitochondrial membrane potential (MMP)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells
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Concentration:1, 3 and 9 nM
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Incubation Time:48 h
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Result:Observed the presence of nuclear collapse and the enhancement of red and bright blue fluorescence.
Increased the early apoptosis rates of MCF-7 cells ranged from 1.92% to 16.87%, while the late apoptosis rates ranged from 0.23% to 19.43%.
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Cell Line:MCF-7 cells
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Concentration:1, 3 and 9 nM
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Incubation Time:24 h
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Result:Promoted the G2/M phase block in a concentration-dependent manner.
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Cell Line:MCF-7 cells
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Concentration:1, 3 and 9 nM
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Incubation Time:48 h
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Result:Significantly upregulated the levels of cytochrome c and cleaved caspase 8.
Increased the ratio of cleaved PARP to PARP.
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Cell Line:MCF-7 cells
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Concentration:1, 3 and 9 nM
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Incubation Time:24 h
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Result:Increased the ROS levels by 30.67 %, 65.33 %, and 168.00 %, respectively.
Caused the MMP of MCF-7 cells depolarizes with increasing concentrations, which is characterized by a gradual decrease in the red/green fluorescence ratio.
Chemical Information
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CAS No. 3085940-57-1
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Masse moléculaire 721.77
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Formule C39H53BrN4O4
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SMILES
C[C@@]12[C@](C[C@@]3([H])[C@]2([H])[C@@H]([C@H](O3)CC[C@@H](C)C(NCC4=CN(N=N4)CC5=CC=C(C=C5)Br)=O)C)([H])[C@@]6([H])[C@]([C@@]7(C(C[C@H](CC7)OC(C)=O)=CC6)C)([H])CC1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Apoptosis inducer 41 Related Classifications
HY-175567 Related Classifications
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