BAY-u 9773
Based on 1 publication(s) in Google Scholar
BAY-u 9773 is a selective cysteinyl-leukotriene receptor antagonist. BAY-u 9773 competitively antagonizes cysteinyl-leukotriene-induced contractions at typical and atypical cysteinyl-leukotriene receptors with comparable activity. BAY-u 9773 can be used for the research of trichomoniasis.
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- CAS No.: 154978-38-8
- Formule: C27H36O5S
- Masse moléculaire:472.64
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Stockage:
-80°C, protect from light
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) BAY-u 9773
MoreVoir tous les produits spécifiques à Isoform Leukotriene Receptor
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Activité biologique
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CysLT1 |
CysLT2 |
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Cell Line
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Type | Value | Description | References |
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| CHO | IC50 |
0.44 μM
Compound: BAY-u9773
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Antagonist activity at human CysLT1 receptor expressed in CHO cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay
Antagonist activity at human CysLT1 receptor expressed in CHO cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay
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[PMID: 25408836] |
| HEK293 | IC50 |
0.3 μM
Compound: BAY-u9773
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Antagonist activity at human CysLT2 receptor expressed in HEK293 cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay
Antagonist activity at human CysLT2 receptor expressed in HEK293 cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay
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[PMID: 25408836] |
BAY u9773 (10 nM-10 μM; 15 min) competitively displaces [3H] leukotriene D4 binding to guinea-pig lung membranes with a mean pKi of 7.0[1].
BAY-u 9773 (1-10 μM; 30 min pretreatment) dose-dependently inhibits TvSP- and LTC4-induced MCP-1 secretion in HMC-1 cells, with the strongest effect observed at 10 μM[2].
BAY-u 9773 (1-5 μM) dose-dependently inhibits TvSP- and LTC4-induced ROS production in HMC-1 cells, with significant suppression at concentrations ≥1 μM[2].
BAY-u 9773 (5 μM) inhibits TvSP- and LTC4-induced migration of HMC-1 cells by approximately 60%[2].
BAY-u 9773 (1-5 μM) dose-dependently inhibits TvSP- and LTC4-induced degranulation (measured via CD63 expression) in HMC-1 cells, with the strongest effect at 5 μM[2].
BAY-u 9773 inhibits TvSP-induced p47phox phosphorylation in HMC-1 cells[2].
BAY-u 9773 inhibits TvSP- and LTC4-induced NF-κB phosphorylation in HMC-1 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HMC-1
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Concentration:1 μM; 3 μM; 10 μM
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Incubation Time:30 min pretreatment
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Result:Dose-dependently inhibited TvSP-induced MCP-1 secretion, reducing levels to ~260 pg/mL at 10 μM compared to ~460 pg/mL in untreated TvSP-stimulated cells.
Dose-dependently inhibited LTC4-induced MCP-1 secretion, reducing levels to ~270 pg/mL at 10 μM compared to ~460 pg/mL in untreated LTC4-stimulated cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 154978-38-8
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Appearance Liquid
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Masse moléculaire 472.64
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Formule C27H36O5S
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Color Colorless to light yellow
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SMILES
OC(CCC[C@H](O)[C@@H](/C=C/C=C/C=C\C/C=C\CCCCC)SC1=CC=C(C=C1)C(O)=O)=O
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Livraison
Shipping with dry ice.
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Stockage
-80°C, protect from light
Publications (1)
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Journal Impact Factor
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Most Recent
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J Biol Chem
MGST3 regulates BACE1 protein translation and amyloidogenesis by controlling the RGS4-mediated AKT signaling pathway. [Abstract]2024 Aug;300(8):107530. PMID: 38971310
Pureté et documentation
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Fiche technique (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Tudhope SR, et al. BAY u9773, a novel antagonist of cysteinyl-leukotrienes with activity against two receptor subtypes. Eur J Pharmacol. 1994;264(3):317-323. [Content Brief]
[2]. Lee YA, et al. Trichomonas vaginalis-secreted cysteinyl leukotrienes promote migration, degranulation and MCP-1 production in mast cells. Parasite Immunol. 2020;42(12):e12789. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BAY-u 9773 Related Classifications
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