BGC1614
BGC1614 is a Nectin-4-targeting bicyclic toxin conjugate (BTC) belonging to the category of peptide-drug conjugates (PDCs). BGC1614 exhibits strong targeted binding ability to Nectin-4, with an KD of 3.859 × 10-7 M. BGC1614 exhibits superior antitumor efficacy in nude mice bearing PC-3 and N87 tumor xenografts. BGC1614 can be used for research related to Nectin-4-overexpressing tumors (such as prostate cancer, gastric cancer).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C387H582N94O104S7
- Masse moléculaire:8439.78
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:PC-3 or N87 cells were implanted into nude mice[1]
-
Dosage:1.0, 3.0 mg/kg
-
Administration:i.v., once a week, 21 days
-
Result:Achieved tumor growth inhibition (TGI) rates of 96.3% in nude mice bearing PC-3 tumor xenografts.
Achieved tumor growth inhibition (TGI) rates of 41.9% and 70.1% respectively in nude mice bearing N87 tumor xenografts.
Showed no significant changes in body weight.
Chemical Information
-
Masse moléculaire 8439.78
-
Formule C387H582N94O104S7
-
Sequence
Mpa-Pro-Nal-(DAsp)-Cys-Met-hArg-Asp-Trp-Ser-Thr-Pro-HyP-Trp-Cys(TATA covalent with Mpa1,Cys5,Cys15)-Sar10-PEG6-Lys(Lys(N3)-(DBCO-PEG6-βAla-Sar10-Ala-hArg-Asp-Cys-Hyp-Leu-Val-Asn-Pro-Leu-Cys-Leu-His-Pro-(DAsp)-Trp-hArg-Cysteamine, TATA covalent with Cys15,Cys22,Cysteamine 29)-GA-Val-Cit-PABC-MMAE
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BGC1614 Related Classifications
HY-178489 Related Classifications
Powered by Bioz