BMS-193884
BMS-193884 is a selective, orally active, and competitive ETA antagonist with 10000-fold greater affinity for the human ETA receptor (Ki=1.4 nM) than for the ETB receptor.
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- CAS No.: 176960-47-7
- Formule: C20H17N3O4S
- Masse moléculaire:395.43
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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ETA 1.4 nM (Ki) |
ETB 18700 nM (Ki) |
Chemical Information
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CAS No. 176960-47-7
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Masse moléculaire 395.43
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Formule C20H17N3O4S
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SMILES
O=S(C1=CC=CC=C1C2=CC=C(C3=NC=CO3)C=C2)(NC4=C(C)C(C)=NO4)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Murugesan N, et al. Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist. J Med Chem. 2003;46(1):125-137. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMS-193884 Related Classifications
HY-19263 Related Classifications
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